Recombinant Human CD4 therapeutic protein

Cat.No.: CD4-P022H
Product Overview: The therapeutic protein is a form of recombinant CD4 derived from Pneumonas aeruginosa
exotoxin A.
Description: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Source: Pneumonas aeruginosa exotoxin A
Species: Human
Endotoxin: < 0.1 EU per μg of the protein
Purity: >97%
Gene Name: CD4 CD4 molecule [ Homo sapiens ]
Official Symbol: CD4
Synonyms: CD4; CD4 molecule; CD4 antigen (p55) , T cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4mut;
Gene ID: 920
mRNA Refseq: NM_000616
Protein Refseq: NP_000607
MIM: 186940
UniProt ID: P01730
Chromosome Location: 12p13.31
Pathway: Adaptive Immune System, organism-specific biosystem; Alpha-defensins, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Arf1 pathway, organism-specific biosystem; Binding and entry of HIV virion, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem;
Function: MHC class II protein binding; coreceptor activity; enzyme binding; extracellular matrix structural constituent; glycoprotein binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity; transmembrane signaling receptor activity; zinc ion binding;

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