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Recombinant Human Aminopeptidase N(ANPEP) ,partial

Cat.No.: ANPEP-250H
Product Overview: Recombinant Human ANPEP extracellular domain(858-967aa), fussed with His-sumo-tag at C-terminal, was expressed in E. coli.
Description: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.
Source: E. coli
Species: Human
Tag: His-sumo
Form: Tris-based buffer,50% glycerol
Protein length: 858-967aa
Purity: >90%
Stability: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage: Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade.
Shipping: 30-40 work days
Gene Name: ANPEP alanyl (membrane) aminopeptidase [ Homo sapiens ]
Official Symbol: ANPEP
Synonyms: APN; CD13; LAP1; P150; PEPN; GP150; aminopeptidase N; AP-M; AP-N; alanyl aminopeptidase; aminopeptidase M; hAPN; microsomal aminopeptidase; myeloid plasma membrane glycoprotein CD13
Gene ID: 290
mRNA Refseq: NM_001150
Protein Refseq: NP_001141
MIM: 151530
UniProt ID: P15144
Chromosome Location: 15q25-q26
Pathway: C-MYB transcription factor network, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Metabolic pathways, organism-specific biosystem
Function: aminopeptidase activity; metallopeptidase activity; receptor activity

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