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Active Recombinant Mouse Ldlr Protein, His-tagged

Cat.No. : Ldlr-646M
Product Overview : Recombinant Mouse Ldlr (Accession # NP_034830) Ala22-Arg790, fused with a C-terminal 10-His tag, was produced in Mouse myeloma cell line, NS0-derived.
  • Specification
  • Gene Information
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Source : Mammalian cells
Species : Mouse
Tag : His
Predicted N Terminal : Ala22
Form : Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Bio-activity : Measured by its ability to bind immobilized human LDL in a functional ELISA.
Molecular Mass : Recombinant Mouse Ldlr, His-tagged has a calculated MW of 85.7 kDa. In SDS-PAGE migrates as 130-135 kDa, reducing conditions.
Protein length : Ala22-Arg790
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Reconstitution : Reconstitute at 100 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Gene Name : Ldlr low density lipoprotein receptor [ Mus musculus ]
Official Symbol : Ldlr
Synonyms : LDLR; low density lipoprotein receptor; low-density lipoprotein receptor; LDL receptor; Hlb301;
Gene ID : 16835
mRNA Refseq : NM_001252658
Protein Refseq : NP_001239587
MIM :

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there conditions where upregulation of LDLR might be beneficial? 03/17/2022

Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

Are there ongoing research efforts regarding LDLR and its clinical applications? 09/02/2021

Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

What are the clinical implications of LDLR dysfunction? 09/01/2020

Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

How does LDLR impact atherosclerosis? 05/27/2020

A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

What treatment options exist for LDLR-related conditions? 02/23/2018

Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.

Customer Reviews (3)

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Reviews
08/11/2020

    The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

    10/07/2018

      Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

      03/04/2017

        the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

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