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| Cat. No.: | CXCL14-90H |
| Product Overview: | Recombinant human BRAK produced inE.coliis a 9.4 kDa protein containing 77 amino acid residues. |
| Description: | Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. |
| Source: | E.coli. |
| Purity: | > 98% by SDS-PAGE and HPLC analysis. |
| Endotoxin level: | < 0.1 ng per μg of BRAK. |
| Stabilizer: | None. |
| Formulation: | Lyophilized. |
| Biologically Activity: | Determined by it"s ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml. |
| Reconstitution: | The human BRAK should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C. |
| Stability: | The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted BRAK is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene Name: | CXCL14 chemokine (C-X-C motif) ligand 14 [ Homo sapiens ] |
| Synonyms: | CXCL14; chemokine (C-X-C motif) ligand 14; KS1; Kec; BMAC; BRAK; NJAC; MIP-2g; SCYB14; MGC10687; bolekine; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK); Small-inducible cytokine B14; C-X-C motif chemokine 14; UNQ240/PRO273; bolekine; CXC chemokine in breast and kidney; Chemokine BRAK; Chemokine BRAK; chemokine (C-X-C motif) ligand 14; small inducible cytokine subfamily B (Cys-X-Cys), member 14(BRAK) |
| Gene ID: | 9547 |
| mRNA Refseq: | NM_004887 |
| Protein Refseq: | NP_004878 |
| MIM: | 604186 |
| UniProt ID: | O95715 |
| Chromosome Location: | 5q31 |
| Pathway: | Chemokine signaling pathway; Cytokine-cytokine receptor interaction |
| Function: | chemokine activity |
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