Recombinant Human FLT3, GST-tagged, Active
Cat.No. : | FLT3-319H |
Product Overview : | Recombinant human FLT3 (571-993) was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=73kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FLT3-319H |
Description : | FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors. FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30 to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3. The consequence of either FLT3-ITD or activating loop mutations is the constitutive activation of the tyrosine kinase activity. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 571-993. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ] |
Synonyms : | FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; tal liver kinase 2; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III; C 2.7.10.1; OTTHUMP00000042340; fetal liver kinase 2 |
Gene ID : | 2322 |
mRNA Refseq : | NM_004119 |
Protein Refseq : | NP_004110 |
UniProt ID : | P36888 |
Chromosome Location : | 13q12 |
MIM : | 136351 |
Pathway : | ute myeloid leukemia; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer |
Function : | ATP binding; nucleotide binding; osphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity |
Products Types
◆ Recombinant Protein | ||
FLT3-2340H | Recombinant Human FLT3 Protein, MYC/DDK-tagged | +Inquiry |
FLT3-088H | Recombinant Human FLT3 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Flt3-10555M | Recombinant Mouse Flt3 Protein, His (Fc)-Avi-tagged | +Inquiry |
FLT3-4370H | Active Recombinant Human FLT3 Protein, GST-tagged | +Inquiry |
FLT3-038H | Recombinant Human FLT3 Protein, C-His-tagged | +Inquiry |
◆ Lysates | ||
FLT3-2561HCL | Recombinant Human FLT3 cell lysate | +Inquiry |
FLT3-970MCL | Recombinant Mouse FLT3 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1592 | Flt3 ActivityAssay Kit | +Inquiry |
Kit-1593 | Flt3 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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