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Recombinant Human CDC-like Kinase 1, GST-tagged, Active

Cat.No. : CLK1-284H
Product Overview : Recombinant human CLK1 (129-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=66 kDa.
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Cat. No. : CLK1-284H
Description : CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins, such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors.
Source : Sf9 insect cellsusing baculovirus.
Sequence : 129-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : CLK1 CDC-like kinase 1 [ Homo sapiens ]
Synonyms : CLK1; CDC-like kinase 1; CLK; STY; CLK/STY; CDC28/CDC2-like kinase; protein tyrosine kinase STY; dual specificity protein kinase CLK1; EC 2.7.12.1
Gene ID : 1195
mRNA Refseq : NM_001162407
Protein Refseq : NP_001155879
MIM : 601951
UniProt ID : P49759
Chromosome Location : 2q33
Function : ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is CLK1 expression regulated in normal physiological conditions? 10/18/2020

CLK1 expression is tightly regulated at transcriptional and post-translational levels, ensuring its proper function in normal cellular processes.

How is CLK1 activity measured in research settings? 06/09/2020

Researchers often measure CLK1 activity through in vitro kinase assays or by monitoring its phosphorylation targets in cellular or tissue samples.

Can targeting CLK1 have implications for neurodegenerative diseases? 06/09/2018

Yes, studies suggest that CLK1 inhibitors may have therapeutic potential for neurodegenerative disorders by modulating RNA splicing.

Are there any known CLK1 mutations associated with diseases? 09/16/2017

Some studies suggest that CLK1 mutations may be associated with certain diseases, but further research is needed to establish clear links.

Are there any CLK1 inhibitors under development for cancer treatment? 01/21/2016

Yes, several CLK1 inhibitors are in preclinical and clinical development as potential anticancer agents.

Customer Reviews (3)

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Reviews
01/31/2021

    The manufacturer's commitment to customer satisfaction extends beyond technical support. They offer a comprehensive range of related products and resources to aid researchers in their trials.

    01/22/2019

      From troubleshooting to optimizing experimental protocols, the manufacturer provides diligent support to ensure the success of the trial.

      09/28/2018

        The CLK1 protein offers several advantageous features that make it an ideal choice for researchers conducting trials.

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