Recombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active
Cat.No. : | Pik3ca/PIK3R1-390H |
Product Overview : | Recombinant full-length mouse p110alpha and human p85alpha were co-expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag on both proteins. MW=111 kDa (p110α), ~86 kDa (p85α). |
- Specification
- Gene Information
- Related Products
Cat. No. : | Pik3ca/PIK3R1-390H |
Description : | The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110α catalytic subunit (PIK3CA) is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants. PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of p110α is essential for vascular development and inactivation of p110α leads to severe defects in angiogenic sprouting and vascular remodeling . |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [ Mus musculus ],PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Homo sapiens ] |
Synonyms : | Pik3ca; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; p110; caPI3K; MGC161268; p110alpha; 6330412C24Rik; PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); p85; GRB1; p85-ALPHA |
Gene ID : | 18706,5295 |
mRNA Refseq : | NM_008839,NM_181504 |
Protein Refseq : | NP_032865,NP_852556 |
UniProt ID : | P42337, P27986 |
Chromosome Location : | 3 12.4 cM, 5q13.1 |
MIM : | 171833 |
Pathway : | Calcium signaling pathway; Insulin signaling pathway; Metabolism of carbohydrates; Chronic myeloid leukemia; Pancreatic cancer; Pathways in cancer; Small cell lung cancer; T cell receptor signaling pathway; Acute myeloid leukemia; Colorectal cancer; Endometrial cancer; Fc gamma R-mediated phagocytosis; Fc epsilon RI signaling pathway; Acute myeloid leukemia; Jak-STAT signaling pathway; Leukocyte transendothelial migration; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Phosphatidylinositol signaling; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus; VEGF signaling pathway; mTOR signaling pathway |
Function : | ATP binding; nucleotide binding; transferase activity; 1-phosphatidylinositol-3-kinase activity; inositol or phosphatidylinositol kinase activity; insulin receptor substrate binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotransferase activity, alcohol group as acceptor; ErbB-3 class receptor binding |
Products Types
◆ Recombinant Protein | ||
PIK3CA-2591H | Recombinant Human PIK3CA Protein, His-tagged | +Inquiry |
PIK3CA-3250R | Recombinant Rhesus Macaque PIK3CA Protein, His (Fc)-Avi-tagged | +Inquiry |
PIK3CA-3860H | Recombinant Human PIK3CA Protein, His (Fc)-Avi-tagged | +Inquiry |
PIK3CA-6737M | Recombinant Mouse PIK3CA Protein, His (Fc)-Avi-tagged | +Inquiry |
PIK3CA&PIK3R3-152H | Active Recombinant Human PIK3CA/PIK3R3 protein, His-tagged | +Inquiry |
◆ Lysates | ||
PIK3CA-3189HCL | Recombinant Human PIK3CA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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