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Recombinant Human B2M

Cat.No. : B2M-26790TH
Product Overview : Recombinant full length human beta 2 Microglobulin, 11.76 kDa.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
Source : E. coli
Form : Lyophilised:It is recommended to reconstitute the lyophilized B2M in sterile 18M-cm H2O not less than 100ug/ml,which can then be further diluted to other aqueous solutions.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: 0.05% Sodium AzideConstituents: PBS, pH 7.4
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Gene Name : B2M beta-2-microglobulin [ Homo sapiens ]
Official Symbol : B2M
Synonyms : B2M; beta-2-microglobulin;
Gene ID : 567
mRNA Refseq : NM_004048
Protein Refseq : NP_004039
MIM : 109700
Uniprot ID : P61769
Chromosome Location : 15q21-q22.2
Pathway : Adaptive Immune System, organism-specific biosystem; Amyloids, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem;
Function : protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the normal reference range for B2M? 11/19/2019

The normal reference range for B2M varies depending on age, gender, weight, individual differences, and other factors. In general, the normal reference range is between 0~3.0mg/L.

Why is B2M reduced? 11/16/2019

Causes of reduced B2M include liver and kidney failure, tuberculosis, HIV infection, rheumatoid arthritis, systemic lupus erythematosus and other diseases.

In which diseases does B2M play a role in the diagnosis and treatment? 09/20/2019

B2M plays an important role in the diagnosis and prognosis assessment of malignancies such as lymphoma and multiple myeloma. Elevated B2M levels can also indicate worsening or recurrence of certain autoimmune diseases, such as systemic lupus erythematosus.

What are the physiological functions of B2M? 07/29/2019

It has a variety of physiological functions in the immune system, including inducing immune response, participating in lymphocyte proliferation and differentiation, regulating immune tolerance, and participating in tumor immune surveillance.

What are the causes of elevated B2M? 06/05/2019

The levels can be affected by a variety of factors, such as cancer, inflammation, autoimmune diseases, infections, medications, etc.

How is B2M related to disease? 04/30/2019

This is associated with many diseases, including lymphoma, normal stress hydrocephalus, HIV infection, rheumatoid arthritis, nephrotic syndrome, cirrhosis, systemic lupus erythematosus, etc.

Customer Reviews (3)

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Reviews
10/08/2022

    To meet the needs of biological activity experiments

    01/25/2022

      High purity, no impurities.

      09/10/2020

        The expression level is high, which can meet the daily experimental needs.

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