Native Human CNTF

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Native Human CNTF

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Cat.No. : CNTF-26839TH
Product Overview : Recombinant full length human CNTF; 199 amino acids, 22706 Daltons.
Description : The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
Source : E. coli
Tissue specificity : Nervous system.
Form : Lyophilised:Reconstitute in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions..
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: ddH20, 5mM Sodium chloride, 5mM Sodium phosphate buffer, pH 7.5
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Phe-Thr-Glu.
Sequence Similarities : Belongs to the CNTF family.
Gene Name : CNTF ciliary neurotrophic factor [ Homo sapiens ]
Official Symbol : CNTF
Synonyms : CNTF; ciliary neurotrophic factor; HCNTF;
Gene ID : 1270
mRNA Refseq : NM_000614
Protein Refseq : NP_000605
MIM : 118945
Uniprot ID : P26441
Chromosome Location : 11q12
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : ciliary neurotrophic factor receptor binding; cytokine activity; growth factor activity; interleukin-6 receptor binding;

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