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Native Human CNTF

Cat.No.: CNTF-26839TH
Product Overview: Recombinent full length human CNTF; 199 amino acids, 22706 Daltons.
Description: The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
Source: E. coli
Tissue specificity: Nervous system.
Form: Lyophilised:Reconstitute in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions..
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: ddH20, 5mM Sodium chloride, 5mM Sodium phosphate buffer, pH 7.5
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Phe-Thr-Glu.
Sequence Similarities: Belongs to the CNTF family.
Gene Name: CNTF ciliary neurotrophic factor [ Homo sapiens ]
Official Symbol: CNTF
Synonyms: CNTF; ciliary neurotrophic factor; HCNTF;
Gene ID: 1270
mRNA Refseq: NM_000614
Protein Refseq: NP_000605
MIM: 118945
Uniprot ID: P26441
Chromosome Location: 11q12
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function: ciliary neurotrophic factor receptor binding; cytokine activity; growth factor activity; interleukin-6 receptor binding;

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