Recombinant Human FOXA2

• Cat.No.: FOXA2-28944TH
• Product Overview: Recombinant full length Human FOXA2; amino acids 1-457, MWt 48.3kDa.

Specification

• Description: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
• Molecular Weight: 48.300kDa
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 500mM L-arginine, 300mM Guanidine-HCl, 50mM HEPES, 5mM Cystamine, 5mM Cysteamine, 5mM Calcium chloride, 3mM DTT, pH 7.5
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 fork-head DNA-binding domain.

Gene Information

• Gene Name: FOXA2 forkhead box A2 [ Homo sapiens ]
• Official Symbol: FOXA2
• Synonyms: FOXA2; forkhead box A2; hepatocyte nuclear factor 3, beta , HNF3B; hepatocyte nuclear factor 3-beta
• Gene ID: 3170
• mRNA Refseq: NM_021784
• Protein Refseq: NP_068556
• MIM: 600288
• Uniprot ID: Q9Y261
• Chromosome Location: 20p11
• Pathway: Developmental Biology, organism-specific biosystem; FOXA transcription factor networks, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Heart Development, organism-specific biosystem
• Function: DNA bending activity; DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding; SMAD binding; double-stranded DNA binding