Recombinant Human Cytotoxic T-lymphocyte-associated Protein 4, Fc-His

Cat. No. : CTLA4-1598H
Product Overview : Recombinant human CTLA-4 encoding amino acid residue 37-161 of the extracellular domain was fused to the Fc region of human IgG1 with six his residues added at the carboxy-terminus, cloned into a suitable expression vector and was expressed inSf 21 cells.
Description : CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system. CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells. CTLA4 is potentially therapeutic in auto-immune diseases, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment.
Molecular Weight : The predicted molecular weight of Recombinant Human CTLA-4 is Mr 40 kDa.
Source : Sf 21 Insect Cells.
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Human CTLA-4 was determined by its ability to inhibit IL-2 production by Jurkat cells stimulated with Raji cells or 1 μg/ml rhB7-1/Fc in the presence of PHA. The expected ED50 is typically 2 - 4 μg/ml with Raji cells or 0.1 - 0.4 μg/ml with rhB7-H1/Fc.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ]
Synonyms : CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; CD28; CD152; CD152; CELIAC3; CTLA-4; celiac disease 3; Cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; ICOS; GSE; IDDM12; IDDM12; CTLA-4; OTTHUMP00000163781
Gene ID : 1493
mRNA Refseq : NM_001037631
Protein Refseq : NP_001032720
MIM : 123890
UniProt ID : P16410
Chromosome Location : 2q33
Pathway : Autoimmune thyroid disease ; Cell adhesion molecules (CAMs); T cell receptor signaling pathway
Function : Protein binding

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