Recombinant Human WD Repeat Domain 5, His-tagged
Cat.No. : | WDR5-2734H |
Product Overview : | Recombinant humanWDR5 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 38.8 kDa (354aa),confirmed by MALDI-TOF. |
- Specification
- Gene Information
- Related Products
Cat. No. : | WDR5-2734H |
Description : | WDR5, also designated BMP-2-induced gene 3 kb or BIG-3, belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. This protein is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. WDR5 may play a role in its function of accelerating osteoblast differentiation. |
Source : | E.coli. |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL WDYSKGKCLK TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH TDVVISTACH PTENIIASAA LENDKTIKLW KSDC |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl. |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | WDR5 WD repeat domain 5 [ Homo sapiens ] |
Synonyms : | WDR5; WD repeat domain 5; SWD3; BIG-3; WD repeat-containing protein 5; WD-repeat protein 5; BMP2-induced 3-kb gene protein; SWD3, Set1c WD40 repeat protein, homolog; SWD3, Set1c WD40 repeat protein, homolog (S. cerevisiae) |
Gene ID : | 11091 |
mRNA Refseq : | NM_017588 |
Protein Refseq : | NP_060058 |
MIM : | 609012 |
UniProt ID : | P61964 |
Chromosome Location : | 9q34 |
Function : | contributes_to histone methyltransferase activity (H3-K4 specific); protein binding |
Products Types
◆ Recombinant Protein | ||
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WDR5-007H | Recombinant Human WDR5 Protein | +Inquiry |
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WDR5-31543TH | Recombinant Human WDR5, His-tagged | +Inquiry |
◆ Lysates | ||
WDR5-343HCL | Recombinant Human WDR5 293 Cell Lysate | +Inquiry |
WDR5-344HCL | Recombinant Human WDR5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, WDR5 has been associated with neurodevelopmental disorders, suggesting a role in non-cancerous diseases as well.
WDR5 regulates the expression of genes critical for neural development, and dysregulation can lead to developmental disorders.
Elevated levels of WDR5 in certain cancers can serve as a diagnostic marker when detected in patient samples.
Yes, there are ongoing clinical trials to test the safety and efficacy of WDR5-targeted therapies in cancer patients.
Some studies suggest a potential link between WDR5 and autoimmune diseases, but further research is needed to confirm this association.
Customer Reviews (3)
Write a reviewTheir ability to accommodate the requirements of large-scale experiments and guarantee a reliable supply streamlines my research operations, eliminating any concerns related to potential shortages.
I am confident that the protein will reliably perform in my assays, providing accurate and reproducible results.
the manufacturer's supply management capabilities assure a seamless and continuous provision of the WDR5 protein.
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