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Recombinant Human WD Repeat Domain 5, His-tagged

Cat.No. : WDR5-2734H
Product Overview : Recombinant humanWDR5 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 38.8 kDa (354aa),confirmed by MALDI-TOF.
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Cat. No. : WDR5-2734H
Description : WDR5, also designated BMP-2-induced gene 3 kb or BIG-3, belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. This protein is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. WDR5 may play a role in its function of accelerating osteoblast differentiation.
Source : E.coli.
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL WDYSKGKCLK TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH TDVVISTACH PTENIIASAA LENDKTIKLW KSDC
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.
Purity : > 95% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : WDR5 WD repeat domain 5 [ Homo sapiens ]
Synonyms : WDR5; WD repeat domain 5; SWD3; BIG-3; WD repeat-containing protein 5; WD-repeat protein 5; BMP2-induced 3-kb gene protein; SWD3, Set1c WD40 repeat protein, homolog; SWD3, Set1c WD40 repeat protein, homolog (S. cerevisiae)
Gene ID : 11091
mRNA Refseq : NM_017588
Protein Refseq : NP_060058
MIM : 609012
UniProt ID : P61964
Chromosome Location : 9q34
Function : contributes_to histone methyltransferase activity (H3-K4 specific); protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can WDR5 play a role in non-cancerous diseases? 03/25/2023

Yes, WDR5 has been associated with neurodevelopmental disorders, suggesting a role in non-cancerous diseases as well.

How does WDR5 affect neurodevelopment? 11/09/2021

WDR5 regulates the expression of genes critical for neural development, and dysregulation can lead to developmental disorders.

How can WDR5 be used as a diagnostic marker for cancer? 03/02/2019

Elevated levels of WDR5 in certain cancers can serve as a diagnostic marker when detected in patient samples.

Are there any clinical trials involving WDR5-targeted therapies? 02/25/2018

Yes, there are ongoing clinical trials to test the safety and efficacy of WDR5-targeted therapies in cancer patients.

Is there a connection between WDR5 and autoimmune diseases? 03/29/2017

Some studies suggest a potential link between WDR5 and autoimmune diseases, but further research is needed to confirm this association.

Customer Reviews (3)

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Reviews
11/25/2020

    Their ability to accommodate the requirements of large-scale experiments and guarantee a reliable supply streamlines my research operations, eliminating any concerns related to potential shortages.

    10/10/2020

      I am confident that the protein will reliably perform in my assays, providing accurate and reproducible results.

      09/25/2017

        the manufacturer's supply management capabilities assure a seamless and continuous provision of the WDR5 protein.

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