Recombinant Human Interleukin 1 Receptor Accessory Protein-Like 1

• Cat.No.: IL1RAP-1638H

Specification

• Cat. No.: IL1RAP-1638H
• Description: IL-1R accessory protein (IL-1RAcP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL-1-dependent activation of transcription factors and gene expression. IL-1R AcP represents a novel target for blocking IL-1 function in human disease.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-1 R3 is Mr 67.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-75 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: L1RAP interleukin 1 receptor accessory protein [ Homo sapiens ]
• Synonyms: IL1RAP; interleukin 1 receptor accessory protein; IL1R3; C3orf13; FLJ37788; IL-1RAcP; OTTHUMP00000209486; OTTHUMP00000209487; OTTHUMP00000209489; OTTHUMP00000209492; interleukin-1 receptor accessory protein beta; IL-1 receptor accessory protein; IL-1RAcP
• Gene ID: 3556
• mRNA Refseq: NM_002182
• Protein Refseq: NP_002173
• MIM: 602626
• UniProt ID: Q9NPH3
• Chromosome Location: 3q28
• Pathway: Apoptosis; Cytokine-cytokine receptor interaction
• Function: interleukin-1 receptor activity; protein binding; transmembrane receptor activity