"IL28A" Related Products


Recombinant Human Interleukin 28A (Interferon, Lambda 2), His-tagged

Cat. No.: IL28A-221H
Product Overview: Recombinant Human interleukin 28A DNA sequence encoding the signal peptide from human CD33 was fused to the carboxylterminally his-tagged mature human IL-29 (Gly 20 - Thr 200) was expressed ina mouse NSO Cells.
Description: Interleukin-28A (IL-28A) also known as IFNL2 is a novel cytokine that exerts its biological effects through a receptor that also binds IL28B and IL29. IL28A induces phosphorylation of STAT1, STAT2, and STAT3. IL-28A has antiviral activities and stimulates antiviral responses through a heterodimeric receptor. IL-28A represents a potential novel approach for therapy of Th1-mediated inflammatory diseases such as T-cell-mediated hepatitis.
Source: NSO Cells.
Molecular Weight: The predicted molecular weight of Recombinant Human IL-28A is Mr 20.8 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 24 kDa.
State Of Matter: Lyophilized.
Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity: > 97% by SDS Page and analyzed by silver stain.
Endotoxin: < 1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Human IFN-λ2 was determined by in an anti-viral assay using human HepG2 cells infected with encephalomyocarditis virus. The expected ED50 for this effect is typically 1 - 5 ng/mL.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: IL28A interleukin 28A (interferon, lambda 2) [ Homo sapiens ]
Synonyms: IL28A; interleukin 28A (interferon, lambda 2);IFNL2; IL-28A; IFN-lambda-2; interferon lambda 2; interferon-lambda 2; Interleukin-28A; Interferon lambda-2; IFN-lambda-2; ZCYTO20; Cytokine ZCYTO20
Gene ID: 282616
mRNA Refseq: NM_172138
Protein Refseq: NP_742150
UniProt ID: Q8IZJ0
Chromosome Location: 19q13.13
MIM: 607401
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: Cytokine activity

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