Recombinant Human MAP3K14 MAP3K14-30381TH

Recombinant Human MAP3K14

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Recombinant Human MAP3K14

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Cat.No. : MAP3K14-30381TH
Product Overview : Recombinant Fragment from Human MAP3K14
Description : This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Tissue specificity : Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.
Biological activity : The protein has a GST tag.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongstot heproteink inasesuper family.STE Ser/Thrpro teinkinase family.MAP kinasekina sekinasesu bfamily.Co ntains1pro teinkinase domain.
Gene Name : MAP3K14 mitogen-activated protein kinase kinase kinase 14 [ Homo sapiens ]
Official Symbol : MAP3K14
Synonyms : MAP3K14; mitogen-activated protein kinase kinase kinase 14; FTDCR1B; HS; HSNIK; NIK; serine/threonine protein kinase;
Gene ID : 9020
mRNA Refseq : NM_003954
Protein Refseq : NP_003945
MIM : 604655
Uniprot ID : Q99558
Chromosome Location : 17q21-q22
Pathway : Adaptive Immune System, organism-specific biosystem; Alternative NF-kappaB pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; CD28 co-stimulation, organism-specific biosystem;
Function : ATP binding; MAP kinase kinase kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding;

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