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Recombinant Human Interleukin 29 (Interferon, Lambda 1), His-tagged

Cat. No.: IL29-222H
Product Overview: Recombinant Human interleukin 29 DNA sequence encoding the signal peptide from human CD33 was fused to the carboxylterminally his-tagged mature human IL-29 (Gly 20 - Thr 200). The chimeric protein was expressed in a mouseNSO Cells.
Description: Interleukin-29 (IL-29), also known as IFN-lambda1, is a protein of the helical cytokine family and is a type III interferon. It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 stimulates antiviral responses through a heterodimeric receptor. It plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses.
Source: NSO Cells.
Molecular Weight: The predicted molecular weight of Recombinant Human IL-29 is Mr 21.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 26-35 kDa.
State Of Matter: Lyophilized.
Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity: > 95% by SDS Page and analyzed by silver stain.
Endotoxin: < 1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Human IFN-Lambda1 was determined in an anti-viral assay using human HepG2 cells infected with encephalomyocarditis. The expected ED50 for this effect is typically 1 - 5 ng/mL.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: IL29 interleukin 29 (interferon, lambda 1) [ Homo sapiens ]
Synonyms: IL29; IL-29; IFNL1; IL-28A; IL-28B; IFN-lambda-1; ZCYTO21; interferon-λ2 (IFN-λ2); IFN-λ3; and IFN-λ1; Cytokine ZCYTO21; Interferon lambda-1; interferon, lambda 1; interleukin 29; interleukin 29 (interferon, lambda 1)
Gene ID: 282618
mRNA Refseq: NM_172140
Protein Refseq: NP_742152
UniProt ID: Q8IU54
Chromosome Location: 19q13.13
MIM: 607403
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: cytokine activity; interleukin-28 receptor binding

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