Native Human PLAU

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Native Human PLAU

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Cat.No. : PLAU-31687TH
Product Overview : Full length native Human Urokinase from Human urine conjugated to HRP, 54kDa.
Description : This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimers disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein length : 411 amino acids
Molecular Weight : 54.000kDa
Tissue specificity : Expressed in the prostate gland and prostate cancers.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.1M Sodium chloride, 0.05M Sodium acetate, 1mM EDTA, pH 5.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the peptidase S1 family.Contains 1 EGF-like domain.Contains 1 kringle domain.Contains 1 peptidase S1 domain.
Gene Name : PLAU plasminogen activator, urokinase [ Homo sapiens ]
Official Symbol : PLAU
Synonyms : PLAU; plasminogen activator, urokinase; urokinase-type plasminogen activator; UPA; URK;
Gene ID : 5328
mRNA Refseq : NM_001145031
Protein Refseq : NP_001138503
MIM : 191840
Uniprot ID : P00749
Chromosome Location : 10q24
Pathway : ATF-2 transcription factor network, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem;
Function : peptidase activity; protein binding; serine-type endopeptidase activity;

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