"RCAN1" Related Products

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Recombinant Human RCAN1

Cat.No.: RCAN1-27792TH
Product Overview: Recombinant fragment: MKLYFAQTLHIGSSHLAPP N PDKQFLIS PP ASPPVGW KQV EDATPV INYD LLYAI SKLGP , corresponding to N terminal amino acids 1-117 of Human Calcipressin 1
Description: The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
Source: E. coli
Tissue specificity: Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 0.1M Sodium chloride, 20mM Tris 7.5, 1mM DTT
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids: MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGPGEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS
Sequence Similarities: Belongs to the RCAN family.
Gene Name: RCAN1 regulator of calcineurin 1 [ Homo sapiens ]
Official Symbol: RCAN1
Synonyms: RCAN1; regulator of calcineurin 1; Down syndrome critical region gene 1 , DSCR1; calcipressin-1;
Gene ID: 1827
mRNA Refseq: NM_004414
Protein Refseq: NP_004405
MIM: 602917
Uniprot ID: P53805
Chromosome Location: 21q22.1-q22.2
Pathway: Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem;
Function: DNA binding; protein binding; sequence-specific DNA binding transcription factor activity;

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