Recombinant Human S100A12, His-tagged S100A12-30229TH

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Gene Information
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Cat.No.:	S100A12-30229TH
Product Overview:	Recombinant full length Human S100A12 with an N terminal His tag; 101 amino acids with tag, predicted MWt: 11.6 kDa.
Description:	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.
Protein length:	91 amino acids
Conjugation:	HIS
Molecular Weight:	11.600kDa inclusive of tags
Source:	E. coli
Tissue specificity:	Monocytes and lymphocytes.
Form:	Lyophilised:Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Filter the product by an appropriate sterile filter before using it in the cell culture.
Purity:	by SDS-PAGE
Storage buffer:	Preservative: NoneConstituents: 50mM Sodium chloride, 20mM Tris, pH 7.5
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids:	MKHHHHHHAS TKLEEHLEGI VNIFHQYSVR KGHFDTLSKG ELKQLLTKEL ANTIKNIKDK AVIDEIFQGL DANQDEQVDFQEFISLVAIA LKAAHYHTHK E
Sequence Similarities:	Belongs to the S-101 family.Contains 2 EF-hand domains.

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Gene Name:	S100A12 S100 calcium binding protein A12 [ Homo sapiens ]
Official Symbol:	S100A12
Synonyms:	S100A12; S100 calcium binding protein A12; S100 calcium binding protein A12 (calgranulin C) , S100 calcium binding protein A12 (calgranulin C); protein S100-A12; CAAF1; CAGC; CGRP; ENRAGE; MRP6; p6;
Gene ID:	6283
mRNA Refseq:	NM_005621
Protein Refseq:	NP_005612
MIM:	603112
Uniprot ID:	P80511
Chromosome Location:	1q21
Pathway:	Activated TLR4 signalling, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem;
Function:	RAGE receptor binding; RAGE receptor binding; calcium ion binding; protein binding; zinc ion binding;