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Recombinant Human S100B

Cat.No. : S100B-31009TH
Product Overview : Recombinant full length protein, corresponding to amino acids 1-92 of Human S100 beta
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimers disease, Downs syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Source : E. coli
Tissue specificity : Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50mM Potassium chloride, 30mM HEPES, pH 6.5Note: Under these conditions, to avoid precipitation, the product can be concentrated to a maximum of 0.2mM (dimer).
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the S-101 family.Contains 2 EF-hand domains.
Gene Name : S100B S100 calcium binding protein B [ Homo sapiens ]
Official Symbol : S100B
Synonyms : S100B; S100 calcium binding protein B; S100 calcium binding protein, beta (neural); protein S100-B; S100beta;
Gene ID : 6285
mRNA Refseq : NM_006272
Protein Refseq : NP_006263
MIM : 176990
Uniprot ID : P04271
Chromosome Location : 21q22.3
Pathway : Activated TLR4 signalling, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem;
Function : RAGE receptor binding; S100 beta binding; calcium ion binding; calcium-dependent protein binding; identical protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does S100B help in the diagnosis of traumatic brain injury (TBI)? 01/29/2023

Elevated S100B levels in the blood can indicate TBI, and its measurement can aid in TBI diagnosis and severity assessment.

What conditions can S100B be used to diagnose? 01/11/2023

S100B can be used to diagnose brain injuries, such as traumatic brain injury and stroke.

How is S100B measured in clinical settings? 02/24/2020

S100B levels are typically measured through a blood test.

What precautions should be taken when interpreting S100B results? 02/02/2017

Results should be interpreted in the context of the patient's clinical history and other diagnostic tests.

How is S100B used in the context of neurodegenerative diseases? 02/07/2016

S100B may help in monitoring disease progression and severity in conditions like Alzheimer's disease.

Customer Reviews (3)

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Reviews
03/15/2022

    One major advantage of S100B protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.

    09/29/2019

      The S100B protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

      10/23/2018

        The manufacturer of S100B protein plays a crucial role in supporting my research efforts.

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