"PAK2" Related Products

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Recombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 2

Cat. No.: PAK2-521H
Product Overview: Recombinant Human PAK2 (amino acids 227-524) was expressed inE.coli.MW=33.5 kDa.
Description: Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Source: E.Coli.
Formulated In: 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol, and 5 mM DTT.
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Stability: >6 months at -80°C.
Gene Name: PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 [ Homo sapiens ]
Synonyms: p21 protein (Cdc42/Rac)-activated kinase 2; PAK65; PAKgamma; PAK2; p21-activated kinase 2; S6/H4 kinase; p21 (CDKN1A)-activated kinase 2; EC 2.7.11.1; PAK-2; Gamma-PAK; p58
Gene ID: 5062
mRNA Refseq: NM_002577
Protein Refseq: NP_002568
MIM: 605022
UniProt ID: Q13177
Chromosome Location: 3q29
Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; MAPK signaling pathway; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
Function: ATP binding; identical protein binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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