"TIMP1" Related Products

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Recombinant Human TIMP1, MBP-tagged

Cat.No.: TIMP1-30841TH
Product Overview: Recombinant full length Human TIMP1 with MBP tag; 615 amino acids with tag, MWt 67.8kDa.
Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Conjugation: MBP
Source: E. coli
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 200mM Sodium chloride, 20mM Tris HCl, 1mM EDTA, 1mM DTT,10mM Maltose
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protease inhibitor I35 (TIMP) family.Contains 1 NTR domain.
Gene Name: TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens ]
Official Symbol: TIMP1
Synonyms: TIMP1; TIMP metallopeptidase inhibitor 1; CLGI, TIMP, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); metalloproteinase inhibitor 1; EPO;
Gene ID: 7076
mRNA Refseq: NM_003254
Protein Refseq: NP_003245
MIM: 305370
Uniprot ID: P01033
Chromosome Location: Xp11.3-p11.23
Pathway: Hemostasis, organism-specific biosystem; IL6-mediated signaling events, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem;
Function: enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding;

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