||Recombinant Human Ephrin A1 (C-terminus fused with human IgG1 Fc) produced inmammalian cellscontains 416 amino acids with predicted MW 47.53 KD x 2 (dimmer), and 10 cysteines (Fc has 6).It also has 1 N-link glycosylation site with MW increase up to 5 KD.
||Human Ephrin A1 binds to the receptor tyrosine kinase EphA2, EphA4, EphA5, EphA6 and EphA7. Also binds with low affinity to EphA1. Ephrins are a family of molecules which bind to tyrosine kinase receptor Eph. The Eph receptor and their membrane-attached ligands, ephrins, show diverse expression patterns during development. The crucial roles of Eph and ephrins during development suggest involvement of these genes in congenital disorders affecting the nervous system and other tissues. Eph receptors and ephrins may be involved in carcinogenesis.
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