Recombinant Human Ephrin-A1, Fc Chimera
Cat.No. : | EFNA1-2060H |
Product Overview : | Recombinant Human Ephrin A1 (C-terminus fused with human IgG1 Fc) produced inmammalian cellscontains 416 amino acids with predicted MW 47.53 KD x 2 (dimmer), and 10 cysteines (Fc has 6).It also has 1 N-link glycosylation site with MW increase up to 5 KD. |
- Specification
- Gene Information
- Related Products
Cat. No. : | EFNA1-2060H |
Description : | Human Ephrin A1 binds to the receptor tyrosine kinase EphA2, EphA4, EphA5, EphA6 and EphA7. Also binds with low affinity to EphA1. Ephrins are a family of molecules which bind to tyrosine kinase receptor Eph. The Eph receptor and their membrane-attached ligands, ephrins, show diverse expression patterns during development. The crucial roles of Eph and ephrins during development suggest involvement of these genes in congenital disorders affecting the nervous system and other tissues. Eph receptors and ephrins may be involved in carcinogenesis. |
Source/Host : | mammalian cells. |
Purity : | >90%. |
Availability : | back order, one month for production. |
Recommended Storage Temperature : | -70°C. |
Gene Name : | EFNA1 ephrin-A1 [ Homo sapiens ] |
Synonyms : | EFNA1; B61; ECKLG; EFL1; EPLG1; LERK-1; TNFAIP4; Ephrin-A1; OTTHUMP00000033242; OTTHUMP00000033271; EPH-related receptor tyrosine kinase ligand 1; Immediate early response protein B61; Tumor necrosis factor, alpha-induced protein 4; Ligand of eph-related kinase 1 |
Gene ID : | 1942 |
mRNA Refseq : | NM_004428 |
Protein Refseq : | NP_004419 |
MIM : | 191164 |
UniProt ID : | P20827 |
Chromosome Location : | 1q21-q22 |
Pathway : | Axon guidance |
Function : | Ephrin receptor binding |
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◆ Lysates | ||
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EFNA1-2177MCL | Recombinant Mouse EFNA1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, EFNA1 is being investigated as a potential therapeutic target in cancer treatment, aiming to develop drugs that modulate its activity.
Researchers are exploring the use of EFNA1 as a biomarker for cancer detection, with studies suggesting its potential as a diagnostic tool.
EFNA1 binds to Eph receptors, initiating cell signaling pathways that regulate various cellular processes, making this interaction crucial for normal physiological functions.
EFNA1 is implicated in cancer progression, influencing cell migration and invasion. Understanding its role can potentially lead to targeted therapies for certain cancers.
Dysregulation of EFNA1 has been linked to certain neurological disorders, including Alzheimer's disease and neurodevelopmental disorders.
Customer Reviews (3)
Write a reviewTheir prompt assistance and willingness to go above and beyond to ensure my success have been immensely valuable.
Its purity, stability, and consistency are unparalleled, ensuring reliable and reproducible results in my research.
This protein has proven to be an invaluable asset in my experiments, enabling accurate and precise measurements with exceptional sensitivity.
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