Recombinant Human Melanoma Cell Adhesion Molecule

• Cat.No.: MCAM-2391H
• Product Overview: Recombinant Human Melanoma Cell Adhesion Molecule(aa 433-647) is expressed inE.coli. MW=47kDa.

Specification

• Cat. No.: MCAM-2391H
• Description: CD146 belongs to the immunoglobulin supergene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions. CD146 has a molecular size of 130 kDa in its reduced form (118 kDa unreduced), and N linked glycosylation accounts for fifty percent of the apparent molecular weight. In some cells the molecule carries a sulfate 3 glucuronyl moiety.
• Source: E. coli.
• Presentation: 100μl purified human CD146 protein at 100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide.
• Application: ELISA, Inhibition Assays, Western Blotting.
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 47kDa including GST.
• Storage: Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months.

Gene Information

• Gene Name: MCAM melanoma cell adhesion molecule [ Homo sapiens ]
• Synonyms: MCAM; melanoma cell adhesion molecule; CD146; MUC18; Gicerin; melanoma adhesion molecule; Cell surface glycoprotein MUC18; Melanoma-associated antigen MUC18; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; S-endo 1 endothelial-associated antigen; Cell surface glycoprotein P1H12; S-endo 1 endothelial-associated antigen; Cell surface glycoprotein P1H12
• Gene ID: 4162
• mRNA Refseq: NM_006500
• Protein Refseq: NP_006491
• MIM: 155735
• UniProt ID: P43121
• Chromosome Location: 11q23.3
• Function: protein binding