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Recombinant Human Melanoma Cell Adhesion Molecule

Cat. No. : MCAM-2391H
Product Overview : Recombinant Human Melanoma Cell Adhesion Molecule(aa 433-647) is expressed inE.coli. MW=47kDa.
Description : CD146 belongs to the immunoglobulin supergene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions. CD146 has a molecular size of 130 kDa in its reduced form (118 kDa unreduced), and N linked glycosylation accounts for fifty percent of the apparent molecular weight. In some cells the molecule carries a sulfate 3 glucuronyl moiety.
Source : E. coli.
Presentation : 100μl purified human CD146 protein at 100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide.
Application : ELISA, Inhibition Assays, Western Blotting.
Characterization : On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 47kDa including GST.
Storage : Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months.
Gene Name : MCAM melanoma cell adhesion molecule [ Homo sapiens ]
Synonyms : MCAM; melanoma cell adhesion molecule; CD146; MUC18; Gicerin; melanoma adhesion molecule; Cell surface glycoprotein MUC18; Melanoma-associated antigen MUC18; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; S-endo 1 endothelial-associated antigen; Cell surface glycoprotein P1H12; S-endo 1 endothelial-associated antigen; Cell surface glycoprotein P1H12
Gene ID : 4162
mRNA Refseq : NM_006500
Protein Refseq : NP_006491
MIM : 155735
UniProt ID : P43121
Chromosome Location : 11q23.3
Function : protein binding

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