"USP14" Related Products

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Recombinant Human USP14

Cat. No.: USP14-692H
Product Overview: Recombinant Human USP14 isproduced inE. coli.
Description: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Source: E. coli.
Storage: -80°C.
Gene Name: USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) [ Homo sapiens ]
Synonyms: USP14; ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); deubiquitinating enzyme 14; tRNA-guanine transglycosylase, 60-kD subunit; ubiquitin carboxyl-terminal hydrolase 14; ubiquitin specific protease 14 (tRNA-guanine transglycosylase); ubiquitin thioesterase 14; ubiquitin thiolesterase 14; ubiquitin-specific processing protease 14; ubiquitin-specific-processing protease 14; TGT; EC 3.1.2.15
Gene ID: 9097
mRNA Refseq: NM_001037334
Protein Refseq: NP_001032411
MIM: 607274
UniProt ID: P54578
Chromosome Location: 18p11.32
Function: cysteine-type endopeptidase activity; peptidase activity; proteasome binding; proteasome inhibitor activity; tRNA guanylyltransferase activity; ubiquitin thiolesterase activity; ubiquitin-specific protease activity

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