"CHUK" Related Products

Recombinant Human CHUK, His-tagged

Cat. No. : CHUK-675H
Product Overview : Recombinant human full length CHUK, His-tagged was expressed ininsect cells.MW = 88.7 kDa.
Description : Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in mediating the inflammatory response. In addition, IKK-α functions independently of the IκB kinase complex to regulate epidermal differentiation.
Source : Insect cells.
Formulation : Liquid in 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2mM DTT + 50% glycerol.
Specific Activity : 38 nmole of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33 µg/ml.
Storage & Stability : Stable for 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
Gene Name : CHUK conserved helix-loop-helix ubiquitous kinase [ Homo sapiens ]
Synonyms :
conserved helix-loop-helix ubiquitous kinase; IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha; CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha; TCF-16; IKK-a kinase; ikappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; transcription factor 16; IkB kinase alpha subunit; conserved helix-loop ubiquitous kinase; Nuclear factor NFkappaB inhibitor kinase alpha; nuclear factor NF-kappa-B inhibitor kinase alpha;Nuclear factor NF-kappa-B inhibitor kinase alpha; Transcription factor 16; IkappaB kinase; IKK-A; EC
Gene ID : 1147
mRNA Refseq : NM_001278
Protein Refseq : NP_001269
MIM : 600664
UniProt ID : O15111
Chromosome Location : 10q24-q25
Pathway : Acute myeloid leukemia; Adipocytokine signaling pathway; Apoptosis; B cell receptor signaling pathway; Chagas disease; Chemokine signaling pathway; Chronic myeloid leukemia; Cytosolic DNA-sensing pathway; Epithelial cell signaling in Helicobacter pylori infection; MAPK signaling pathway; NOD-like receptor signaling pathway; Pancreatic cancer; Pathways in cancer; Prostate cancer; RIG-I-like receptor signaling pathway; Shigellosis; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Signaling in Immune system
Function : ATP binding; IkappaB kinase activity; identical protein binding; nucleotide binding; protein binding; protein heterodimerization activity; transferase activity

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