Recombinant Human PAK2, GST-His PAK2-721H

Recombinant Human PAK2, GST-His

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Recombinant Human PAK2, GST-His

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Cat. No. : PAK2-721H
Product Overview : Recombinant Human PAK2, Amino acids D3-R52, N-terminally fused to GST-HIS6-Thrombin cleavage site, was expressed inSf9 cells. MW = 87,954 Da.
Description : The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Source : Baculovirus infected Sf9 cells.
Purification : One-step affinity purification using GSH-agarose.
Product Identity : PAK2 was confirmed as PAK2 by specific Western Blotting using anti PAK2 antibody.
Storage Buffer : 50 mM Tris-HCl, pH 8.0; 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol.
Concentration : 0.403 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity : 228 pmol/μg×min.
Storage : -80°C. Avoid repeated freeze-thaw cycles!
PDB rendering based on 1e0a. :

Gene Name : PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 [ Homo sapiens ]
Synonyms : PAK2; p21 protein (Cdc42/Rac)-activated kinase 2; PAK65; PAKgamma; p21-activated kinase 2; S6/H4 kinase; p21 (CDKN1A)-activated kinase 2; EC 2.7.11.1; PAK-2; Gamma-PAK; p58
Gene ID : 5062
mRNA Refseq : NM_002577
Protein Refseq : NP_002568
MIM : 605022
UniProt ID : Q13177
Chromosome Location : 3q29
Pathway : Axon guidance; ErbB signaling pathway; Focal adhesion; MAPK signaling pathway; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
Function : ATP binding; identical protein binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity

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