"PAK2" Related Products

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Recombinant Human PAK2, GST-His

Cat. No.: PAK2-721H
Product Overview: Recombinant Human PAK2, Amino acids D3-R52, N-terminally fused to GST-HIS6-Thrombin cleavage site, was expressed inSf9 cells. MW = 87,954 Da.
Description: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Source: Baculovirus infected Sf9 cells.
Purification: One-step affinity purification using GSH-agarose.
Product Identity: PAK2 was confirmed as PAK2 by specific Western Blotting using anti PAK2 antibody.
Storage Buffer: 50 mM Tris-HCl, pH 8.0; 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol.
Concentration: 0.403 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity: 228 pmol/μg×min.
Storage: -80°C. Avoid repeated freeze-thaw cycles!
Gene Name: PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 [ Homo sapiens ]
Synonyms: PAK2; p21 protein (Cdc42/Rac)-activated kinase 2; PAK65; PAKgamma; p21-activated kinase 2; S6/H4 kinase; p21 (CDKN1A)-activated kinase 2; EC 2.7.11.1; PAK-2; Gamma-PAK; p58
Gene ID: 5062
mRNA Refseq: NM_002577
Protein Refseq: NP_002568
MIM: 605022
UniProt ID: Q13177
Chromosome Location: 3q29
Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; MAPK signaling pathway; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
Function: ATP binding; identical protein binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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