"MAPKAPK5" Related Products

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Recombinant Human MAPKAPK5

Cat. No.: MAPKAPK5-736H
Product Overview: Recombinant Human MAPKAPK5, full length, amino acids M1-Q471, activated, untagged, was expressed inE.coli. MW = 54,161 Da.
Description: MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene.The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites.
Source: E.coli.
Purification: Immobilized Metal Affinity Chromatography.
Product Identity: MAPKAPK5 was confirmed as MAPKAPK5 by mass spectroscopy LC-ESI-MS/MS.
Activation: with MKK6-SDTD / p38-alpha.
Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 20% glycerol.
Concentration: 0.772 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
Specific Activity: 11 pmol/μg×min.
Storage: -80°C. Avoid repeated freeze-thaw cycles!
Gene Name: MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 [ Homo sapiens ]
Synonyms: MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; PRAK; MAP kinase-activated protein kinase 5; MAPKAPK-5; MAPKAP kinase 5; MAPK-activated protein kinase 5; p38-regulated/activated protein kinase; EC 2.7.11.1
Gene ID: 8550
mRNA Refseq: NM_003668
Protein Refseq: NP_003659
MIM: 606723
UniProt ID: Q8IW41
Chromosome Location: 12q24.12-q24.13
Pathway: MAPK signaling pathway
Function: ATP binding; MAP kinase kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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