Recombinant Human Interleukin-16
Cat.No. : | IL16-25H |
Product Overview : | Recombinant Human IL-16 produced in E. coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 13.4 kDa |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL16-25H |
Description : | IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity. |
Purity : | >97% as determined by RP-HPLC, FPLC and SDS-PAGE. |
Formulation : | rHuIL-16 was lyophilized from 1mg/ml solution after extensive dialysis against 20 mM acetic buffer, pH 5.0, 150 mM NaCl and 0.5 mM DTT. |
Specific Activity : | rHuIL-16 is fully biologically active when compared to standard. The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a Specific Activity greater than 1.0 x 104IU/mg. |
Endotoxin : | Less than 0.1ng/µg (1 IEU/µg) determined by LAL test. |
Reconstitution : | It is recommended to reconstitute the lyophilized rHuIL-16 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Storage : | Lyophilized rHuIL-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-16 should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles. |
Gene Name : | IL16 |
Synonyms : | FLJ16806; FLJ42735; FLJ44234; LCF; prIL-16; IL16; Interleukin-16; Lymphocyte Chemoattractant Factor; prIL-16; IL-16; HsT19289 ; interleukin-16 precursor; interleukin 16 (lymphocyte chemoattractant factor) |
Gene ID : | 3603 |
mRNA Refseq : | NM_004513 |
Protein Refseq : | NP_004504 |
MIM : | 603035 |
UniProt ID : | Q14005 |
Chromosome Location : | 15q26.3 |
Pathway : | immune response; induction of positive chemitaxis; leukocyte chemitaxis |
Function : | cytokine activity; protein binding |
Products Types
◆ Recombinant Protein | ||
IL16-1007C | Recombinant Chicken IL16 Protein, His-tagged | +Inquiry |
IL16-181H | Recombinant Human IL16 Protein (Met1203-Ser1332), C-His tagged, Animal-free, Carrier-free | +Inquiry |
Il16-1239M | Recombinant Mouse Il16 Protein, MYC/DDK-tagged | +Inquiry |
IL16-2055R | Recombinant Rhesus Macaque IL16 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL16-135H | Recombinant Human IL16 Protein | +Inquiry |
◆ Native Protein | ||
IL16-29736TH | Native Human IL16 | +Inquiry |
◆ Lysates | ||
IL16-5245HCL | Recombinant Human IL16 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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