Recombinant Active Mouse IL22 Protein, His-tagged(C-ter)
Cat.No. : | Il22-178M |
Product Overview : | Recombinant Active Mouse IL22 Protein with His tag (C-ter) was expressed in E. coli. |
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Description : | Predicted to enable cytokine activity. Acts upstream of or within several processes, including negative regulation of inflammatory response; reactive oxygen species metabolic process; and regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Is expressed in retina and skin. Used to study liposarcoma. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL22 (interleukin 22). |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Powder |
Bio-activity : | Determined by its ability to induce IL-10 secretion in COLO205 cells. The ED50 for this effect is < 0.3 ng/mL. |
AA Sequence : | MLPVNTRCKLEVSNFQQPYIVNRTF MLAKEASLADNNTDVRLIGEKLFRG VSAKDQCYLMKQVLNFTLEDVLLPQ SDRFQPYMQEVVPFLTKLSNQLSSC HISGDDQNIQKNVRRLKETVKKLGE SGEIKAIGELDLLFMSLRNACV |
Endotoxin : | Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test. |
Purity : | > 98% (by SDS-PAGE) |
Applications : | SDS-PAGE |
Notes : | For laboratory research only, not for drug, diagnostic or other use. |
Storage : | Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
Storage Buffer : | PBS (pH 7.4) |
Reconstitution : | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
Gene Name : | Il22 interleukin 22 [ Mus musculus ] |
Official Symbol : | Il22 |
Synonyms : | IL22; interleukin 22; interleukin-22; ILTIF alpha; IL-TIF alpha; interleukin-22a; IL-10-related T-cell-derived-inducible factor; interleukin 10-related T cell-derived inducible factor; IL-22; Iltif; IL-22a; ILTIFa; MGC129416; MGC129417; |
Gene ID : | 50929 |
mRNA Refseq : | NM_016971 |
Protein Refseq : | NP_058667 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewHigh specificity.
Good for Th17 differentiation.
Effective in gut repair assays.
Q&As (10)
Ask a questionIL22 enhances gut epithelial repair mechanisms.
IL22 activates STAT3 to modulate downstream targets.
IL22 interacts synergistically with IL-17 during inflammation.
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
IL22 expression is upregulated in psoriasis.
IL22 expression is upregulated during viral infections like Hepatitis C.
IL22 contributes to anti-tumor immunity by activating NK cells.
IL22 promotes Th22 cell differentiation.
IL22 polymorphisms affect its binding affinity and signaling.
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