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Recombinant Full Length Human FLT3 Protein, C-Flag-tagged

Cat.No. : FLT3-984HFL
Product Overview : Recombinant Full Length Human FLT3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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Description : This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 112.7 kDa
AA Sequence : MPALARGGGQLPLLVVFSAMIFGTI TNQDLPVIKCVLINHKNNDSSVGKS SSYPMVSESPEDLGCALRPQ SSGTVYEAAAVEVDVSASITLQVLV DAPGNISCLWVFKHSSLNCQPHFDL QNRGVVSMVILKMTETQAGE YLLFIQSEATNYTILFTVSIRNTLL YTLRRPYFRKMENQDALVCISESVP EPIVEWVLCDSQGESCKEES PAVVKKEEKVLHELFGMDIRCCARN ELGRECTRLFTIDLNQTPQTTLPQL FLKVGEPLWIRCKAVHVNHG FGLTWELENKALEEGNYFEMSTYST NRTMIRILFAFVSSVARNDTGYYTC SSSKHPSQSALVTIVEKGFI NATNSSEDYEIDQYEEFCFSVRFKA YPQIRCTWTFSRKSFPCEQKGLDNG YSISKFCNHKHQPGEYIFHA ENDDAQFTKMFTLNIRRKPQVLAEA SASQASCFSDGYPLPSWTWKKCSDK SPNCTEEITEGVWNRKANRK VFGQWVSSSTLNMSEAIKGFLVKCC AYNSLGTSCETILLNSPGPFPFIQD NISFYATIGVCLLFIVVLTL LICHKYKKQFRYESQLQMVQVTGSS DNEYFYVDFREYEYDLKWEFPRENL EFGKVLGSGAFGKVMNATAY GISKTGVSIQVAVKMLKEKADSSER EALMSELKMMTQLGSHENIVNLLGA CTLSGPIYLIFEYCCYGDLL NYLRSKREKFHRTWTEIFKEHNFSF YPTFQSHPNSSMPGSREVQIHPDSD QISGLHGNSFHSEDEIEYEN QKRLEEEEDLNVLTFEDLLCFAYQV AKGMEFLEFKSCVHRDLAARNVLVT HGKVVKICDFGLARDIMSDS NYVVRGNARLPVKWMAPESLFEGIY TIKSDVWSYGILLWEIFSLGVNPYP GIPVDANFYKLIQNGFKMDQ PFYATEEIYIIMQSCWAFDSRKRPS FPNLTSFLGCQLADAEEAMYQNVDG RVSECPHTYQNRRPFSREMD
LGLLSPQAQVEDSTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways : Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer
Gene Name : FLT3 fms related receptor tyrosine kinase 3 [ Homo sapiens (human) ]
Official Symbol : FLT3
Synonyms : FLK2; STK1; CD135; FLK-2
Gene ID : 2322
mRNA Refseq : NM_004119.3
Protein Refseq : NP_004110.2
MIM : 136351
UniProt ID : P36888

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
08/01/2021

    Excellent product, great price.

    12/22/2020

      Satisfied, will order again.

      09/14/2020

        Quick response, helpful service.

        Q&As (7)

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        How is FLT3 implicated in acute myeloid leukemia (AML)? 12/24/2021

        FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

        In which cells or tissues is FLT3 predominantly expressed? 07/08/2021

        FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

        How does FLT3 contribute to hematopoiesis? 03/15/2021

        It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

        Are there therapeutic strategies targeting FLT3 for disease treatment? 08/01/2020

        Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

        What is the primary biological function of FLT3 in cells? 06/27/2020

        FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

        What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells? 07/14/2019

        It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

        What are the common mutations found in FLT3 associated with diseases? 04/05/2019

        Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.

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