Recombinant Full Length Human NR2C2 Protein, C-Flag-tagged

• Cat.No.: NR2C2-1900HFL
• Product Overview: Recombinant Full Length Human NR2C2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 67.2 kDa
• AA Sequence: MTSPSPRIQIISTDSAVASPQRIQG SEPASGPLSVFTSLNKEKIVTDQQT GQKIQIVTAVDASGSPKQQF ILTSPDGAGTGKVILASPETSSAKQ LIFTTSDNLVPGRIQIVTDSASVER LLGKTDVQRPQVVEYCVVCG DKASGRHYGAVSCEGCKGFFKRSVR KNLTYSCRSNQDCIINKHHRNRCQF CRLKKCLEMGMKMESVQSER KPFDVQREKPSNCAASTEKIYIRKD LRSPLIATPTFVADKDGARQTGLLD PGMLVNIQQPLIREDGTVLL ATDSKAETSQGALGTLANVVTSLAN LSESLNNGDTSEIQPEDQSASEITR AFDTLAKALNTTDSSSSPSL ADGIDTSGGGSIHVISRDQSTPIIE VEGPLLSDTHVTFKLTMPSPMPEYL NVHYICESASRLLFLSMHWA RSIPAFQALGQDCNTSLVRACWNEL FTLGLAQCAQVMSLSTILAAIVNHL QNSIQEDKLSGDRIKQVMEH IWKLQEFCNSMAKLDIDGYEYAYLK AIVLFSPDHPGLTSTSQIEKFQEKA QMELQDYVQKTYSEDTYRLA RILVRLPALRLMSSNITEELFFTGL IGNVSIDSIIPYILKMETAEYNGQI TGASL TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

Gene Information

• Gene Name: NR2C2 nuclear receptor subfamily 2 group C member 2 [ Homo sapiens (human) ]
• Official Symbol: NR2C2
• Synonyms: TR4; TAK1
• Gene ID: 7182
• mRNA Refseq: NM_003298.5
• Protein Refseq: NP_003289.2
• MIM: 601426
• UniProt ID: P49116