Human NR2C2 Knockdown Cell Lysate

• Cat.No.: NR2C2-506HKCL
• Product Overview: WB-validated NR2C2 Knockdown HT-1080 Cell Lysate

Specification

• Species: Human
• Source: HT-1080
• Tag: Non
• Description: This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 65 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HT-1080 cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HT-1080 cell lysate 1 vial of 100 μg NR2C2 KD HT-1080 cell lysate
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: NR2C2 nuclear receptor subfamily 2, group C, member 2 [ Homo sapiens (human) ]
• Official Symbol: NR2C2
• Synonyms: NR2C2; nuclear receptor subfamily 2, group C, member 2; TR4; nuclear receptor subfamily 2 group C member 2; hTAK1; TAK1; TR2R1; testicular receptor 4; orphan nuclear receptor TR4; Nuclear hormone receptor TR4; TR4 nuclear hormone receptor; orphan nuclear receptor TAK1; testicular nuclear receptor 4
• Gene ID: 7182
• mRNA Refseq: NM_003298
• Protein Refseq: NP_003289
• MIM: 601426
• UniProt ID: P49116