Recombinant Full Length Human ROR1 Protein, Fc-tagged

• Cat.No.: ROR1-429H
• Product Overview: Recombinant human ROR1 protein with Fc tag was expressed in HEK293.

Specification

• Description: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: 68.6 kDa
• Protein length: 937
• AA Sequence: MHRPRRRGTRPPLLALLAALLLAAR GAAAQETELSVSAELVPTSSWNISS ELNKDSYLTLDEPMNNITTSLGQTA ELHCKVSGNPPPTIRWFKNDAPVVQ EPRRLSFRSTIYGSRLRIRNLDTTD TGYFQCVATNGKEVVSSTGVLFVKF GPPPTASPGYSDEYEEDGFCQPYRG IACARFIGNRTVYMESLHMQGEIEN QITAAFTMIGTSSHLSDKCSQFAIP SLCHYAFPYCDETSSVPKPRDLCRD ECEILENVLCQTEYIFARSNPMILM RLKLPNCEDLPQPESPEAANCIRIG IPMADPINKNHKCYNSTGVDYRGTV SVTKSGRQCQPWNSQYPHTHTFTAL RFPELNGGHSYCRNPGNQKEAPWCF TLDENFKSDLCDIPACDSKDSKEKN KMEILYILVPSVAIPLAIALLFFFI CVCRNNQKSSSAPVQRQPKHVRGQN VEMSMLNAYKPKSKAKELPLSAVRF MEELGECAFGKIYKGHLYLPGMDHA QLVAIKTLKDYNNPQQWTEFQQEAS LMAELHHPNIVCLLGAVTQEQPVCM LFEYINQGDLHEFLIMRSPHSDVGC SSDEDGTVKSSLDHGDFLHIAIQIA AGMEYLSSHFFVHKDLAARNILIGE QLHVKISDLGLSREIYSADYYRVQS KSLLPIRWMPPEAIMYGKFSSDSDI WSFGVVLWEIFSFGLQPYYGFSNQE VIEMVRKRQLLPCSEDCPPRMYSLM TECWNEIPSRRPRFKDIHVRLRSWE GLSSHTSSTTPSGGNATTQTTSLSA SPVSNLSNPRYPNYMFPSQGITPQG QIAGFIGPPIPQNQRFIPINGYPIP PGYAAFPAAHYQPTGPPRVIQHCPP PKSRSPSSASGSTSTGHVTSLPSSG SNQEANIPLLPHMSIPNHPGGMGIT VFGNKSQKPYKIDSKQASLLGDANI HGHTESMISAEL
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: ROR1 receptor tyrosine kinase-like orphan receptor 1 [ Homo sapiens (human) ]
• Official Symbol: ROR1
• Synonyms: ROR1; receptor tyrosine kinase-like orphan receptor 1; NTRKR1; tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase receptor-related 1; neurotrophic tyrosine kinase, receptor-related 1; dJ537F10.1; MGC99659
• Gene ID: 4919
• mRNA Refseq: NM_001083592
• Protein Refseq: NP_001077061
• MIM: 602336
• UniProt ID: Q01973

Reviews

10/18/2022

Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

08/13/2022

Excellent after-sales service, solving many experimental problems.

04/12/2021

Fast and timely shipment helped me to get satisfactory experimental results in short time.

Q&As

What is the expression level of ROR1 in normal tissues.

ROR1 is barely expressed in normal, differentiated and mature tissues, but is highly expressed in tumor tissues.

What are the effects of inhibiting ROR1 expression?

Inhibit the expression of ROR1 can reduce the proliferation and migration ability of tumor cells.

What biological processes is ROR1 involved in?

ROR1 is involved in the regulation of cell metabolism, proliferation, apoptosis, and differentiation.

What diseases is ROR1 involved in?

ROR1 is involved in the study of breast, lung and ovarian cancers.