| Description : |
This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
161 kDa |
| AA Sequence : |
MWAQLLLGMLALSPAIAEELPNYLV TLPARLNFPSVQKVCLDLSPGYSDV KFTVTLETKDKTQKLLEYSGLKKRH LHCISFLVPPPAGGTEEVATIRVSG VGNNISFEEKKKVLIQRQGNGTFVQ TDKPLYTPGQQVYFRIVTMDSNFVP VNDKYSMVELQDPNSNRIAQWLEVV PEQGIVDLSFQLAPEAMLGTYTVAV AEGKTFGTFSVEEYVLPKFKVEVVE PKELSTVQESFLVKICCRYTYGKPM LGAVQVSVCQKANTYWYREVEREQL PDKCRNLSGQTDKTGCFSAPVDMAT FDLIGYAYSHQINIVATVVEEGTGV EANATQNIYISPQMGSMTFEDTSNF YHPNFPFSGKIRVRGHDDSFLKNHL VFLVIYGTNGTFNQTLVTDNNGLAP FTLETSGWNGTDVSLEGKFQMEDLV YNPEQVPRYYQNAYLHLRPFYSTTR SFLGIHRLNGPLKCGQPQEVLVDYY IDPADASPDQEISFSYYLIGKGSLV MEGQKHLNSKKKGLKASFSLSLTFT SRLAPDPSLVIYAIFPSGGVVADKI QFSVEMCFDNQVSLGFSPSQQLPGA EVELQLQAAPGSLCALRAVDESVLL LRPDRELSNRSVYGMFPFWYGHYPY QVAEYDQCPVSGPWDFPQPLIDPMP QGHSSQRSIIWRPSFSEGTDLFSFF RDVGLKILSNAKIKKPVDCSHRSPE YSTAMGAGGGHPEAFESSTPLHQAE DSQVRQYFPETWLWDLFPIGNSGKE AVHVTVPDAITEWKAMSFCTSQSRG FGLSPTVGLTAFKPFFVDLTLPYSV VRGESFRLTATIFNYLKDCIRVQTD LAKSHEYQLESWADSQTSSCLCADE AKTHHWNITAVKLGHINFTISTKIL DSNEPCGGQKGFVPQKGRSDTLIKP VLVKPEGVLVEKTHSSLLCPKGKVA SESVSLELPVDIVPDSTKAYVTVLG DIMGTALQNLDGLVQMPSGCGEQNM VLFAPIIYVLQYLEKAGLLTEEIRS RAVGFLEIGYQKELMYKHSNGSYSA FGERDGNGNTWLTAFVTKCFGQAQK FIFIDPKNIQDALKWMAGNQLPSGC YANVGNLLHTAMKGGVDDEVSLTAY VTAALLEMGKDVDDPMVSQGLRCLK NSATSTTNLYTQALLAYIFSLAGEM DIRNILLKQLDQQAIISGESIYWSQ KPTPSSNASPWSEPAAVDVELTAYA LLAQLTKPSLTQKEIAKATSIVAWL AKQRNAYGGFSSTQDTVVALQALAK YATTAYMPSEEINLVVKSTENFQRT FNIQSVNRLVFQQDTLPNVPGMYTL EASGQGCVYVQTVLRYNILPPTNMK TFSLSVEIGKARCEQPTSPRSLTLT IHTSYVGSRSSSNMAIVEVKMLSGF SPMEGTNQLLLQQPLVKKVEFGTDT LNIYLDELIKNTQTYTFTISQSVLV TNLKPATIKVYDYYLPDEQATIQYS DPCETRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
