Recombinant Human AKR1C3 Protein AKR1C3-01H

Recombinant Human AKR1C3 Protein

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Recombinant Human AKR1C3 Protein

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Cat.No. : AKR1C3-01H
Product Overview : Recombinant human AKR1C3 protein (1-323aa, 323aa) without tag was expressed in E. coli and purified by using conventional chromatography techniques.
Description : This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Form : Liquid
Bio-activity : Specific activity is > 1000 pmol/min/μg, and is defined as the amount of enzyme that catalyze the oxidation of 1.0 pmole 1-Acenaphthenol in the presence of NADP per minute at pH 8.8 at 25 centigrade.
Molecular Mass : 36.8 kDa
Protein length : 1-323
AA Sequence : MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD RNLHYFNSDS FASHPNYPYS DEY
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 90% by SDS-PAGE
Applications : Enzyme Activity, SDS-PAGE
Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/mL (determined by Bradford assay)
Storage Buffer : 20 mM Tris-HCl buffer (pH 8.5) containing 0.1 M NaCl, 10% glycerol, 1 mM DTT
SDS-PAGE :

3 μg by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Gene Name : AKR1C3 aldo-keto reductase family 1 member C3 [ Homo sapiens (human) ]
Official Symbol : AKR1C3
Synonyms : AKR1C3; aldo-keto reductase family 1 member C3; DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS; aldo-keto reductase family 1 member C3; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; chlordecone reductase homolog HAKRb; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; indanol dehydrogenase; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase; EC 1.1.1.188; EC 1.1.1.210; EC 1.1.1.239; EC 1.1.1.357; EC 1.1.1.53; EC 1.1.1.62; EC 1.1.1.64
Gene ID : 8644
mRNA Refseq : NM_003739
Protein Refseq : NP_003730
MIM : 603966
UniProt ID : P42330
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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