Active Recombinant Human AKR1C3 Protein
Cat.No. : | AKR1C3-01H |
Product Overview : | Recombinant human AKR1C3 protein (1-323aa, 323aa) without tag was expressed in E. coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. |
Source : | E. coli |
Species : | Human |
Form : | Liquid |
Bio-activity : | Specific activity is > 1000 pmol/min/μg, and is defined as the amount of enzyme that catalyze the oxidation of 1.0 pmole 1-Acenaphthenol in the presence of NADP per minute at pH 8.8 at 25 centigrade. |
Molecular Mass : | 36.8 kDa |
Protein length : | 1-323 |
AA Sequence : | MDSKHQCVKLNDGHFMPVLGFGTYA PPEVPRSKALEVTKLAIEAGFRHID SAHLYNNEEQVGLAIRSKIADGSVK REDIFYTSKLWSTFHRPELVRPALE NSLKKAQLDYVDLYLIHSPMSLKPG EELSPTDENGKVIFDIVDLCTTWEA MEKCKDAGLAKSIGVSNFNRRQLEM ILNKPGLKYKPVCNQVECHPYFNRS KLLDFCKSKDIVLVAYSALGSQRDK RWVDPNSPVLLEDPVLCALAKKHKR TPALIALRYQLQRGVVVLAKSYNEQ RIRQNVQVFEFQLTAEDMKAIDGLD RNLHYFNSDSFASHPNYPYSDEY |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 90% by SDS-PAGE |
Applications : | Enzyme Activity, SDS-PAGE |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/mL (determined by Bradford assay) |
Storage Buffer : | 20 mM Tris-HCl buffer (pH 8.5) containing 0.1 M NaCl, 10% glycerol, 1 mM DTT |
Gene Name : | AKR1C3 aldo-keto reductase family 1 member C3 [ Homo sapiens (human) ] |
Official Symbol : | AKR1C3 |
Synonyms : | AKR1C3; aldo-keto reductase family 1 member C3; DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS; aldo-keto reductase family 1 member C3; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; chlordecone reductase homolog HAKRb; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; indanol dehydrogenase; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase; EC 1.1.1.188; EC 1.1.1.210; EC 1.1.1.239; EC 1.1.1.357; EC 1.1.1.53; EC 1.1.1.62; EC 1.1.1.64 |
Gene ID : | 8644 |
mRNA Refseq : | NM_003739 |
Protein Refseq : | NP_003730 |
MIM : | 603966 |
UniProt ID : | P42330 |
Products Types
◆ Recombinant Protein | ||
AKR1C3-305H | Recombinant Human AKR1C3 Protein, His (Fc)-Avi-tagged | +Inquiry |
AKR1C3-256R | Recombinant Rat AKR1C3 Protein, His (Fc)-Avi-tagged | +Inquiry |
AKR1C3-50H | Recombinant Human AKR1C3 Protein, His-tagged | +Inquiry |
AKR1C3-090H | Recombinant Human AKR1C3 Protein, His-tagged | +Inquiry |
AKR1C3-9533H | Recombinant Human AKR1C3, GST-tagged | +Inquiry |
◆ Lysates | ||
AKR1C3-49HCL | Recombinant Human AKR1C3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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