Recombinant Human BGLAP Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: BGLAP-010H
• Product Overview: BGLAP MS Standard C13 and N15-labeled recombinant protein (NP_954642) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 8.7 kDa
• AA Sequence: MRALTLLALLALAALCIAGQAGAKP SGAESSKGAAFVSKQEGSEVVKRPR RYLYQWLGAPVPYPDPLEPRREVCE LNPDCDELADHIGFQEAYRRFYGPV TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: BGLAP bone gamma-carboxyglutamate protein [ Homo sapiens (human) ]
• Official Symbol: BGLAP
• Synonyms: BGLAP; bone gamma-carboxyglutamate protein; BGP; OC; OCN; osteocalcin; bone gamma-carboxyglutamate (gla) protein (osteocalcin); gamma-carboxyglutamic acid-containing protein
• Gene ID: 632
• mRNA Refseq: NM_199173
• Protein Refseq: NP_954642
• MIM: 112260
• UniProt ID: P02818