Recombinant Human BMI1 Protein, His tagged

Cat.No. : BMI1-771H
Product Overview : Recombinant Human BMI1 Protein with His tag was expressed in E. coli.
Availability July 20, 2024
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Description : This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : The protein has a calculated MW of 39 kDa.
AA Sequence : MGSSHHHHHHSSGLVPRGSHMHRTT RIKITELNPHLMCVLCGGYFIDATT IIECLHSFCKTCIVRYLETSKYCPI CDVQVHKTRPLLNIRSDKTLQDIVY KLVPGLFKNEMKRRRDFYAAHPSAD AANGSNEDRGEVADEDKRIITDDEI ISLSIEFFDQNRLDRKVNKDKEKSK EEVNDKRYLRCPAAMTVMHLRKFLR SKMDIPNTFQIDVMYEEEPLKDYYT LMDIAYIYTWRRNGPLPLKYRVRPT CKRMKISHQRDGLTNAGELESDSGS DKANSPAGGIPSTSSCLPSPSTPVQ SPHPQFPHISSTMNGTSNSPSGNHQ SSFANRPRKSSVNGSSATSSG
Endotoxin : < 1 EU/μg by LAL
Purity : > 90% by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 0.15 mg/mL by BCA
Storage Buffer : Sterile PBS, pH 7.4
Gene Name : BMI1 BMI1 polycomb ring finger oncogene [ Homo sapiens ]
Official Symbol : BMI1
Synonyms : BMI1; BMI1 polycomb ring finger oncogene; B lymphoma Mo MLV insertion region 1 homolog (mouse), PCGF4, polycomb group ring finger 4; polycomb complex protein BMI-1; RNF51; flvi-2/bmi-1; ring finger protein 51; polycomb group protein Bmi1; polycomb group RING finger protein 4; B lymphoma Mo-MLV insertion region 1 homolog; murine leukemia viral (bmi-1) oncogene homolog; PCGF4; FLVI2/BMI1; MGC12685;
Gene ID : 648
mRNA Refseq : NM_005180
Protein Refseq : NP_005171
MIM : 164831
UniProt ID : P35226

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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