Recombinant Human C3 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | C3-3052H |
Product Overview : | C3 MS Standard C13 and N15-labeled recombinant protein (NP_000055) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 187 kDa |
AA Sequence : | MGPTSGPSLLLLLLTHLPLALGSPM YSIITPNILRLESEETMVLEAHDAQ GDVPVTVTVHDFPGKKLVLSSEKTV LTPATNHMGNVTFTIPANREFKSEK GRNKFVTVQATFGTQVVEKVVLVSL QSGYLFIQTDKTIYTPGSTVLYRIF TVNHKLLPVGRTVMVNIENPEGIPV KQDSLSSQNQLGVLPLSWDIPELVN MGQWKIRAYYENSPQQVFSTEFEVK EYVLPSFEVIVEPTEKFYYIYNEKG LEVTITARFLYGKKVEGTAFVIFGI QDGEQRISLPESLKRIPIEDGSGEV VLSRKVLLDGVQNLRAEDLVGKSLY VSATVILHSGSDMVQAERSGIPIVT SPYQIHFTKTPKYFKPGMPFDLMVF VTNPDGSPAYRVPVAVQGEDTVQSL TQGDGVAKLSINTHPSQKPLSITVR TKKQELSEAEQATRTMQALPYSTVG NSNNYLHLSVLRTELRPGETLNVNF LLRMDRAHEAKIRYYTYLIMNKGRL LKAGRQVREPGQDLVVLPLSITTDF IPSFRLVAYYTLIGASGQREVVADS VWVDVKDSCVGSLVVKSGQSEDRQP VPGQQMTLKIEGDHGARVVLVAVDK GVFVLNKKNKLTQSKIWDVVEKADI GCTPGSGKDYAGVFSDAGLTFTSSS GQQTAQRAELQCPQPAARRRRSVQL TEKRMDKVGKYPKELRKCCEDGMRE NPMRFSCQRRTRFISLGEACKKVFL DCCNYITELRRQHARASHLGLARSN LDEDIIAEENIVSRSEFPESWLWNV EDLKEPPKNGISTKLMNIFLKDSIT TWEILAVSMSDKKGICVADPFEVTV MQDFFIDLRLPYSVVRNEQVEIRAV LYNYRQNQELKVRVELLHNPAFCSL ATTKRRHQQTVTIPPKSSLSVPYVI VPLKTGLQEVEVKAAVYHHFISDGV RKSLKVVPEGIRMNKTVAVRTLDPE RLGREGVQKEDIPPADLSDQVPDTE SETRILLQGTPVAQMTEDAVDAERL KHLIVTPSGCGEQNMIGMTPTVIAV HYLDETEQWEKFGLEKRQGALELIK KGYTQQLAFRQPSSAFAAFVKRAPS TWLTAYVVKVFSLAVNLIAIDSQVL CGAVKWLILEKQKPDGVFQEDAPVI HQEMIGGLRNNNEKDMALTAFVLIS LQEAKDICEEQVNSLPGSITKAGDF LEANYMNLQRSYTVAIAGYALAQMG RLKGPLLNKFLTTAKDKNRWEDPGK QLYNVEATSYALLALLQLKDFDFVP PVVRWLNEQRYYGGGYGSTQATFMV FQALAQYQKDAPDHQELNLDVSLQL PSRSSKITHRIHWESASLLRSEETK ENEGFTVTAEGKGQGTLSVVTMYHA KAKDQLTCNKFDLKVTIKPAPETEK RPQDAKNTMILEICTRYRGDQDATM SILDISMMTGFAPDTDDLKQLANGV DRYISKYELDKAFSDRNTLIIYLDK VSHSEDDCLAFKVHQYFNVELIQPG AVKVYAYYNLEESCTRFYHPEKEDG KLNKLCRDELCRCAEENCFIQKSDD KVTLEERLDKACEPGVDYVYKTRLV KVQLSNDFDEYIMAIEQTIKSGSDE VQVGQQRTFISPIKCREALKLEEKK HYLMWGLSSDFWGEKPNLSYIIGKD TWVEHWPEEDECQDEENQKQCQDLG AFTESMVVFGCPNTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | C3 complement component 3 [ Homo sapiens (human) ] |
Official Symbol : | C3 |
Synonyms : | C3; complement component 3; complement C3; CPAMD1; complement component C3; acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; ASP; AHUS5; ARMD9; |
Gene ID : | 718 |
mRNA Refseq : | NM_000064 |
Protein Refseq : | NP_000055 |
MIM : | 120700 |
UniProt ID : | P01024 |
Products Types
◆ Recombinant Protein | ||
C3-732M | Recombinant Mouse C3 Protein, MYC/DDK-tagged | +Inquiry |
C3-1841H | Recombinant Human C3 Protein, MYC/DDK-tagged | +Inquiry |
C3-2505H | Recombinant Human C3 protein(961-1040 aa), C-His-tagged | +Inquiry |
C3-708R | Recombinant Rat C3 Protein, His (Fc)-Avi-tagged | +Inquiry |
C3-338C | Recombinant Cattle C3 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
C3-012H | Native Human Complement C3c | +Inquiry |
C3-05M | Native Mouse C3 Protein | +Inquiry |
C3-147C | Active Native Botulinum C3 Enzyme | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionYes, a variety of proteins that interact with C3 proteins, including complement receptors, regulatory proteins, inflammatory factors, etc., have been discovered, and they are jointly involved in the regulation and functional execution of C3 proteins.
C3 protein plays an important role in infectious diseases. It can play an anti-infection role by activating the complement system, directly killing pathogens or enhancing the ability of immune cells to destroy pathogens.
Research on C3 protein is going on. At present, it mainly focuses on the analysis of its function and regulatory mechanism, the identification of gene mutations associated with diseases, and the interaction with other complement proteins and immune cells, which provides a theoretical basis for the further development of diagnosis and treatment methods of related diseases.
C3 protein can be used as an aid in the diagnosis of certain immune-related diseases. Measuring the level of C3 protein in serum can reflect the activity of the immune system and the degree of inflammation.
Post-translational modifications of the C3 protein can affect its function. Phosphorylation, cleavage, methylation and other modifications can regulate the activity, stability and interaction ability of C3 proteins.
Yes, some C3 protein-related drug treatments are under development, including drugs that regulate the degree of C3 protein activation, drugs that inhibit the overactivation of C3 protein, etc.
Customer Reviews (3)
Write a reviewExpression efficiency is high. In our experiments, we found that the target protein can be synthesized quickly and effectively.
Activity was not significantly different from the native protein, as expected.
High purity, no obvious impurities.
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