Recombinant Human CCDC50 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: CCDC50-375H
• Product Overview: CCDC50 MS Standard C13 and N15-labeled recombinant protein (NP_777568) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 35.8 kDa
• AA Sequence: MAEVSIDQSKLPGVKEVCRDFAVLE DHTLAHSLQEQEIEHHLASNVQRNR LVQHDLQVAKQLQEEDLKAQAQLQK RYKDLEQQDCEIAQEIQEKLAIEAE RRRIQEKKDEDIARLLQEKELQEEK KRKKHFPEFPATRAYADSYYYEDGG MKPRVMKEAVSTPSRMAHRDQEWYD AEIARKLQEEELLATQVDMRAAQVA QDEEIARLLMAEEKKAYKKAKEREK SSLDKRKQDPEWKPKTAKAANSKSK ESDEPHHSKNERPARPPPPIMTDGE DADYTHFTNQQSSTRHFSKSESSHK GFHYKHTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CCDC50 coiled-coil domain containing 50 [ Homo sapiens (human) ]
• Official Symbol: CCDC50
• Synonyms: CCDC50; coiled-coil domain containing 50; C3orf6, deafness, autosomal dominant 44, DFNA44; coiled-coil domain-containing protein 50; Ymer; protein Ymer; YMER; C3orf6; DFNA44
• Gene ID: 152137
• mRNA Refseq: NM_174908
• Protein Refseq: NP_777568
• MIM: 611051
• UniProt ID: Q8IVM0