Recombinant Human CCN4 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human CCN4 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : CCN4-3463H
Product Overview : WISP1 MS Standard C13 and N15-labeled recombinant protein (NP_003873) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 40.3 kDa
AA Sequence : MRWFLPWTLA AVTAAAASTV LATALSPAPT TMDFTPAPLE DTSSRPQFCK WPCECPPSPP RCPLGVSLIT DGCECCKMCA QQLGDNCTEA AICDPHRGLY CDYSGDRPRY AIGVCAQVVG VGCVLDGVRY NNGQSFQPNC KYNCTCIDGA VGCTPLCLRV RPPRLWCPHP RRVSIPGHCC EQWVCEDDAK RPRKTAPRDT GAFDAVGEVE AWHRNCIAYT SPWSPCSTSC GLGVSTRISN VNAQCWPEQE SRLCNLRPCD VDIHTLIKAG KKCLAVYQPE ASMNFTLAGC ISTRSYQPKY CGVCMDNRCC IPYKSKTIDV SFQCPDGLGF SRQVLWINAC FCNLSCRNPN DIFADLESYP DFSEIANTRT RPLEQKLISE EDLAANDILD YKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : CCN4 cellular communication network factor 4 [ Homo sapiens (human) ]
Official Symbol : CCN4
Synonyms : CCN4; cellular communication network factor 4; WISP1; WISP1c; WISP1i; WISP1tc; WISP1-OT1; WISP1-UT1; CCN family member 4; WISP1 3'UTR-associated RNA 1; WISP1 overlapping transcript 1 (non-protein coding); WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1
Gene ID : 8840
mRNA Refseq : NM_003882
Protein Refseq : NP_003873
MIM : 603398
UniProt ID : O95388

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