Recombinant Human CD4 protein, His-Avi-tagged CD4-293H

Recombinant Human CD4 protein, His-Avi-tagged

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Cat.No. :	CD4-293H
Product Overview :	Human CD40 is expressed from mammalian with a His and a Avi tag at the C-terminal. It contains Glu21-Arg193.
Description :	CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.
Source :	HEK293
Species :	Human
Tag :	His-Avi
Form :	Supplied as 0.22um filtered solution in PBS (pH 7.4).
Molecular Mass :	The protein has a predicted MW of 22.1 kDa. Due to glycosylation, the protein migrates to 35-40 KDa based on Bis-Tris PAGE result.
Protein length :	It contains Glu21-Arg193.
Endotoxin :	Less than 0.1 EU per ug by the LAL method.
Purity :	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Storage :	The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Reconstitution :	It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Tris-Bis PAGE :
HPLC data :

Gene Name :	CD4 CD4 molecule [ Homo sapiens ]
Official Symbol :	CD4
Synonyms :	CD40; CD40L receptor; TNFRSF5; B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CDw40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Gene ID :	920
mRNA Refseq :	NM_000616
Protein Refseq :	NP_000607
MIM :	186940
UniProt ID :	P01730