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Recombinant Human CD59 protein, T7/His-tagged

Cat.No. : CD59-76H
Product Overview : Recombinant human CD59 extracellular domain cDNA (26 - 102 aa) fused with T7-His-TEV cleavage site Tag (29aa) at N-terminal was expressed in E. coli.
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  • Gene Information
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Source : E. coli
Species : Human
Tag : T7/His
Form : 0.50 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
AA Sequence : MASMTGGQQMGRGHHHHHHGNLYFQ GGEFALVQCYNCPNPTADCKTAVNC SSDFDACLITKAGLQVYNKCWKFEH CNFNDVTTRLRENELTYYCCRKDLC NFNEQLEN
Purity : >90% by SDS-PAGE
Applications : 1. Protein can be used as coating matrix protein for CD59 mediated cell functions and differentiation regulation study in vitro.2. As potential disease diagnosis biomarker protein for breast cancer or systemic lupus.3. As antigen for specific antibody production.
Storage : Keep at -80centigrade for long term storage. Product is stable at 4 centigrade for at least 30 days.
Gene Name : CD59 CD59 molecule, complement regulatory protein [ Homo sapiens ]
Official Symbol : CD59
Synonyms : CD59; CD59 molecule, complement regulatory protein; CD59 antigen p18 20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) , CD59 antigen, complement regulatory protein , MIC11, MIN1, MIN2, MIN3, MSK21; CD59 glycoprotein; 16.
Gene ID : 966
mRNA Refseq : NM_000611
Protein Refseq : NP_000602
MIM : 107271
UniProt ID : P13987
Chromosome Location : 11p13
Pathway : Arf6 trafficking events, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem;
Function : protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to explain the role of CD59 in hemolytic disease? 11/30/2022

In hemolytic diseases, the deficiency or dysfunction of CD59 may lead to excessive lysis of red blood cells because the formation of the complement C5b-9 complex cannot be effectively prevented.

Are there differences in CD59 expression levels in different types of cells? 09/30/2022

Yes, the expression level of CD59 can vary in different cell types. In general, it is expressed higher in blood cells and some tumor cells.

What are some of the technical challenges that laboratories may encounter when researching CD59? 12/03/2021

When researching CD59, laboratories may encounter technical challenges such as selecting the appropriate assay, ensuring the quality and consistency of samples, and the complexity of interpreting results. In addition, CD59 expression variations in different cell types and experimental conditions need to be considered.

What diseases are associated with aberrant expression of CD59? 07/19/2020

Aberrant expression of CD59 has been associated with a variety of diseases, including but not limited to hemolytic diseases, certain types of cancer, and autoimmune diseases.

How can I measure CD59 expression in the laboratory? 06/17/2020

CD59 expression can be detected using flow cytometry, immunofluorescence staining, or western blotting.

Is there a current treatment for CD59? 01/01/1900

The current treatment for CD59 is still in the research stage, and there is no drug approved for clinical use. However, some studies are exploring the use of gene therapy or antibody therapy to modulate CD59 expression or function.

Customer Reviews (3)

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Reviews
05/09/2022

    The quality is very high and the reliability is very helpful for our research results.

    03/17/2021

      There are no doping impurities, the experimental effect is very good, and I will recommend it to other students.

      01/13/2021

        Easy to operate and cost-effective.

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