"COL2A1" Related Products

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Recombinant Human COL2A1 protein, His-tagged

Cat.No.: COL2A1-26H
Product Overview: Recombinant Human COL2A1(Gln26-Arg266 & Gly957-Leu1487) fused with His tag at N-terminal was expressed in CHO.
Description: Type II collagen is an essential component of cartilage. It is essential for skeletal development and for the ability of cartilage to resist compressive forces. Type II collagen is a homotrimer of a1(II) chains. Defects in Type II collagen are the cause of numerous diseases, including chondrodysplasias and arthritis. This recombinant mini pro-a1(II) collagen consists of the N‑terminal propeptide, 108 Gly-X-Y repeats, and the C‑terminal propeptide. Proteolytic processing of the C‑terminal propeptide by the procollagen C-proteinase (BMP-1) releases chondrocalcin, a calcium binding protein.
Source: CHO
Species: Human
Tag: His
Predicted N Terminal: His & Asp1242
Form: Supplied as a 0.2 μm filtered solution in Tris and NaCl.
Bio-activity: Measured by the cleavage of its C-terminal propeptide by Recombinant Human BMP‑1/PCP. >50% of full-length Pro-Collagen II is cleaved by Recombinant Human BMP‑1/PCP.
Molecular Mass: Predicted Molecular Mass: 78 kDa;SDS-PAGE: 92-100 kDa, 65-70 kDa, 36 kDa, reducing conditions.
Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
Purity: >85%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain
Storage: Avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 centigrade as supplied.3 months, -70 centigrade under sterile conditions after opening.
Gene Name: COL2A1 collagen, type II, alpha 1 [ Homo sapiens ]
Official Symbol: COL2A1
Synonyms: COL2A1; collagen, type II, alpha 1; collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) , SEDC; collagen alpha-1(II) chain; chondrocalcin; cartilage collagen; alpha-1 type II collagen; collagen II, alpha-1 polypeptide; AOM; ANFH; SEDC; COL11A3; MGC131516;
Gene ID: 1280
mRNA Refseq: NM_001844
Protein Refseq: NP_001835
MIM:
UniProt ID: P02458
Chromosome Location: 12q12-q13.2
Pathway: Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem;
Function: extracellular matrix structural constituent conferring tensile strength; identical protein binding; platelet-derived growth factor binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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