Recombinant Human EGFRviii protein, His-Avi-tagged
Cat.No. : | EGFR-688H |
Product Overview : | Human EGFR vIII Protein is expressed from mammalian with a 6-His and Avi tag at the N-terminal. It contains Leu 25 - Ser 645 (30-297: Val Cys Gln.. Cys Pro Arg → Gly). |
- Specification
- Gene Information
- Related Products
Description : | The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. |
Source : | HEK293 |
Species : | Human |
Tag : | His-Avi |
Form : | Supplied as 0.22um filtered solution in PBS (pH 7.4). |
Molecular Mass : | The protein has a predicted MW of 41.6 kDa .As a result of glycosylation, the protein migrates as 65-80 kDa under reducing (R) condition (Bis-Tris PAGE). |
Protein length : | It contains Leu 25 - Ser 645 (30-297: Val Cys Gln...Cys Pro Arg → Gly). |
Endotoxin : | Less than 0.05 EU per ug by the LAL method. |
Purity : | > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
Storage : | The product should be stored at -70°C. Please do not repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | EGFR epidermal growth factor receptor [ Homo sapiens ] |
Official Symbol : | EGFR |
Synonyms : | EGFRvIII,EGFR |
Gene ID : | 1956 |
mRNA Refseq : | NM_005228 |
Protein Refseq : | NP_005219 |
MIM : | 131550 |
UniProt ID : | P00533 |
Products Types
◆ Recombinant Protein | ||
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EGFR-26H | Recombinant Human EGFR (P772_H773insNP) Mutant Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
EGFR-1462RCL | Recombinant Rat EGFR cell lysate | +Inquiry |
EGFR-663HCL | Recombinant Human EGFR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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