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Recombinant Human EIF2AK3 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : EIF2AK3-2744H
Product Overview : EIF2AK3 MS Standard C13 and N15-labeled recombinant protein (NP_004827) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 125.26 kDa
AA Sequence : MERAISPGLLVRALLLLLLLLGLAA RTVAAGRARGLPAPTAEAAFGLGAA AAPTSATRVPAAGAVAAAEVTVEDA EALPAAAGEQEPRGPEPDDETELRP RGRSLVIISTLDGRIAALDPENHGK KQWDLDVGSGSLVSSSLSKPEVFGN KMIIPSLDGALFQWDRDRESMETVP FTVESLLESSYKFGDDVVLVGGKSL TTYGLSAYSGKVRYICSALGCRQWD SDEMEQEEDILLLQRTQKTVRAVGP RSGNEKWNFSVGHFELRYIPDMETR AGFIESTFKPNENTEESKIISDVEE QEAAIMDIVIKVSVADWKVMAFSKK GGHLEWEYQFCTPIASAWLLKDGKV IPISLFDDTSYTSNDDVLEDEEDIV EAARGATENSVYLGMYRGQLYLQSS VRISEKFPSSPKALESVTNENAIIP LPTIKWKPLIHSPSRTPVLVGSDEF DKCLSNDKFSHEEYSNGALSILQYP YDNGYYLPYYKRERNKRSTQITVRF LDNPHYNKNIRKKDPVLLLHWWKEI VATILFCIIATTFIVRRLFHPHPHR QRKESETQCQTENKYDSVSGEANDS SWNDIKNSGYISRYLTDFEPIQCLG RGGFGVVFEAKNKVDDCNYAIKRIR LPNRELAREKVMREVKALAKLEHPG IVRYFNAWLEAPPEKWQEKMDEIWL KDESTDWPLSSPSPMDAPSVKIRRM DPFSTKEHIEIIAPSPQRSRSFSVG ISCDQTSSSESQFSPLEFSGMDHED ISESVDAAYNLQDSCLTDCDVEDGT MDGNDEGHSFELCPSEASPYVRSRE RTSSSIVFEDSGCDNASSKEEPKTN RLHIGNHCANKLTAFKPTSSKSSSE ATLSISPPRPTTLSLDLTKNTTEKL QPSSPKVYLYIQMQLCRKENLKDWM NGRCTIEERERSVCLHIFLQIAEAV EFLHSKGLMHRDLKPSNIFFTMDDV VKVGDFGLVTAMDQDEEEQTVLTPM PAYARHTGQVGTKLYMSPEQIHGNS YSHKVDIFSLGLILFELLYPFSTQM ERVRTLTDVRNLKFPPLFTQKYPCE YVMVQDMLSPSPMERPEAINIIENA VFEDLDFPGKTVLRQRSRSLSSSGT KHSRQSNNSHSPLPSNTRTRPLEQK LISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 [ Homo sapiens (human) ]
Official Symbol : EIF2AK3
Synonyms : EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3; PEK; PERK; hsPEK; pancreatic EIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase; eukaryotic translation initiation factor 2 alpha kinase 3; WRS; DKFZp781H1925;
Gene ID : 9451
mRNA Refseq : NM_004836
Protein Refseq : NP_004827
MIM : 604032
UniProt ID : Q9NZJ5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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