Recombinant Human FGF1

• Cat.No.: FGF1-013O
• Product Overview: Recombinant Human FGF1 was expressed in Oryza Sativa (Rice Grain).

Specification

• Cat. No.: FGF1-013O
• Introduction: Fibroblast Growth Factor-Acidic (aFGF) is a potent mitogenic agent for a wide variety of mesoderm-derived cells including BALB/c 3T3 fibroblasts, capillary and endocardial endothelial cells, myoblasts, vascular smooth muscle cells, mesothelial cells, glial and astroglial cells, and adrenal cortex cells.1,2 In cells not growth inhibited by heparin (such as baby hamster kidney cells), heparin potentiates the actions of aFGF, but in cells inhibited by heparin (such as bovine brain-derived capillary endothelial cells), no such potentiation is observed.
• Source: Oryza Sativa (Rice Grain)
• Form: Lyophilized Powder
• Applications: 1. Medicine and clinical research: It is considered to function in several important physiological and pathological processes, such as embryonic development, morphogenesis, angiogenesis, wound healing and atheromatosis, carcinogenesis, development, and invasion of cancer. 2. Cosmetic raw material: a) Anti-wrinkle, Anti-oxidant, Skin whitening: aFGF modulates the skin rejuvenating by kstimulation of cell proliferation; Rejuvenates both the epidermal cells and the underlying fibroblast cells, which produce collagen, elastin, and hyaluronic acid, maintain human skin elasticity, and decrease cutaneous senescence; The proliferation of epidermal cells enhanced the skin cells regeneration. b) Rejuvenates hair follicle to produce new hair; aFGF can activate FGF-7, promote hair growth by stimulation of cell proliferation on primary hair cell, treat or prevent baldness.
• Usage: For Research, Laboratory and Manufacture Use. The product should not be used as drugs and food additives.
• Unitprot ID: P05230

Gene Information

• Gene Name: FGF1 fibroblast growth factor 1 (acidic) [ Homo sapiens ]
• Official Symbol: FGF1
• Synonyms: FGF1; AFGF; ECGF; FGFA; ECGFA; ECGFB; HBGF1; GLIO703; ECGF-beta; FGF-alpha; heparin-binding growth factor 1; OTTHUMP00000066027; OTTHUMP00000066028; OTTHUMP00000066030; OTTHUMP00000066031; OTTHUMP00000174675; OTTHUMP00000199418; OTTHUMP00000199419; acidic fibroblast growth factor; beta-endothelial cell growth factor; endothelial cell growth factor, beta; endothelial cell growth factor, alpha
• Gene ID: 2246
• mRNA Refseq: NM_000800
• Protein Refseq: NP_000791
• MIM: 131220
• Chromosome Location: 5q31
• Pathway: Downstream signaling of activated FGFR; FGF signaling pathway; FGFR ligand binding and activation; FGFR1 ligand binding and activation; FGFR2 ligand binding and activation; FGFR3 ligand binding and activation; FGFR4 ligand binding and activation; FRS2-mediated cascade; IRS-mediated signaling; Regulation of Actin Cytoskeleton
• Function: S100 alpha binding; fibroblast growth factor receptor binding; growth factor activity; heparin binding; protein binding; protein tyrosine kinase activity