Active Recombinant Human FGF18 Protein

• Cat.No.: FGF18-031H
• Product Overview: The mature recombinant human FGF-18 protein consists of 180 amino acids (28-207) without tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.
• Source: E. coli
• Species: Human
• Bio-activity: Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGF RIIIc. The ED50 for this effect is 4-24 ng/mL.
• Molecular Mass: 21.2 kDa
• Product-Related Proteins: 28-207
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: FGF18 fibroblast growth factor 18 [ Homo sapiens (human) ]
• Official Symbol: FGF18
• Synonyms: FGF18; fibroblast growth factor 18; ZFGF5; FGF-18; fibroblast growth factor 18
• Gene ID: 8817
• mRNA Refseq: NM_003862
• Protein Refseq: NP_003853
• MIM: 603726
• UniProt ID: O76093