Recombinant Human FLT3 Protein, C-His-tagged
Cat.No. : | FLT3-038H |
Product Overview : | Recombinant Human FLT3 Protein with C-His tag was expressed in E. coli. |
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Description : | FMS-related tyrosine kinase 3 (FLT3, also called Flk2), is a member of the type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system. FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets. The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation. Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~57 kDa |
AA Sequence : | NQDLPVIKCVLINHKNNDSSVGKSS SYPMVSESPEDLGCALRPQSSGTVY EAAAVEVDVSASITLQVLVDAPGNI SCLWVFKHSSLNCQPHFDLQNRGVV SMVILKMTETQAGEYLLFIQSEATN YTILFTVSIRNTLLYTLRRPYFRKM ENQDALVCISESVPEPIVEWVLCDS QGESCKEESPAVVKKEEKVLHELFG TDIRCCARNELGRECTRLFTIDLNQ TPQTTLPQLFLKVGEPLWIRCKAVH VNHGFGLTWELENKALEEGNYFEMS TYSTNRTMIRILFAFVSSVARNDTG YYTCSSSKHPSQSALVTIVEKGFIN ATNSSEDYEIDQYEEFCFSVRFKAY PQIRCTWTFSRKSFPCEQKGLDNGY SISKFCNHKHQPGEYIFHAENDDAQ FTKMFTLNIRRKPQVLAEASASQAS CFSDGYPLPSWTWKKCSDKSPNCTE EITEGVWNRKANRKVFGQWVSSSTL NMSEAIKGFLVKCCAYNSLGTSCET ILLNSPGPFPFIQDNIS |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Concentration : | ≥0.5 mg/mL |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | FLT3 fms-related tyrosine kinase 3 [ Homo sapiens (human) ] |
Official Symbol : | FLT3 |
Synonyms : | FLT3; fms-related tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; CD135; FLK2; STK1; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III; FLK-2; |
Gene ID : | 2322 |
mRNA Refseq : | NM_004119 |
Protein Refseq : | NP_004110 |
MIM : | 136351 |
UniProt ID : | P36888 |
Products Types
◆ Recombinant Protein | ||
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◆ Lysates | ||
FLT3-970MCL | Recombinant Mouse FLT3 cell lysate | +Inquiry |
FLT3-2561HCL | Recombinant Human FLT3 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewExcellent product, great price.
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Q&As (7)
Ask a questionFLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.
FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.
It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.
Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.
FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.
It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.
Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.
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