Recombinant Human FLT3 protein, Fc-tagged FLT3-05H

Recombinant Human FLT3 protein, Fc-tagged

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Recombinant Human FLT3 protein, Fc-tagged

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Cat.No. : FLT3-05H
Product Overview : Recombinant Human FLT3 protein (Asn27-Ser543) was fused to human IgG1 Fc-tag at the C-terminus and expressed in human 293 cells (HEK293).
Description : Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Source : HEK293
Species : Human
Tag : Human IgG1 Fc
Predicted N Terminal : Asn27
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
Molecular Mass : The protein has a calculated MW of 84.8 kDa. The protein migrates as 110-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 517
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
SDS-PAGE of FLT3-05H :

Human Flt-3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA of FLT3-05H :

Immobilized Human Flt-3 Ligand, Tag Free at 1 μg/mL (100 μL/well) can bind Human Flt-3, Fc Tag with a linear range of 2-31 ng/mL (QC tested).

Gene Name : FLT3
Official Symbol : FLT3
Synonyms : FLK2; STK1; CD135; FLK-2
Gene ID : 2322
mRNA Refseq : NM_004119.3
Protein Refseq : NP_004110.2
MIM : 136351
UniProt ID : P36888

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